Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome
| Autor: | Klaus Mann, Susanne Tan, Rainer Kimmig, B. Quadbeck, Onno E. Janssen, Susanne Hahn, U. Haselhorst, Markus Schmidt, S. Roesler |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Type 2 diabetes Endocrinology Insulin resistance Internal medicine Internal Medicine medicine Hyperinsulinemia Vitamin D and neurology Humans Obesity Vitamin D Glucose tolerance test medicine.diagnostic_test business.industry Free androgen index Insulin nutritional and metabolic diseases General Medicine medicine.disease Polycystic ovary Female Insulin Resistance business Hyperandrogenism Polycystic Ovary Syndrome |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 114(10) |
| ISSN: | 0947-7349 |
| Popis: | Insulin resistance (IR) and central obesity are common features of the polycystic ovary syndrome (PCOS). Vitamin D is thought to play a role in the pathogenesis of type 2 diabetes by affecting insulin metabolism. The aim of our study was to investigate the effect of 25-hydroxyvitamin D (25-OH-VD) on metabolic parameters and IR in PCOS. In 120 untreated PCOS patients (median age 28 years) levels of 25-OH-VD (radioimmunoassay method provided by DiaSorin), calcium and anorganic phosphate were measured. In addition, endocrine and metabolic variables were evaluated and a glucose tolerance test was performed to assess indices of IR. In the entire PCOS cohort, 25-OH-VD concentrations were negatively correlated with body mass index (r=-0.2765), body fat (r=-0.2490), HOMA-IR (r=-0.1947), hyperinsulinemia (r=-0.1892) and leptin levels (r=-0.2834), and positively correlated with HDL cholesterol (r=0.2630) (all p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|