Intra-tumoural stromal morphometry predicts disease recurrence but not response to 5-fluorouracil - results from the QUASAR trial of colorectal cancer

Autor: Hutchins, GGA, Treanor, D, Wright, A, Handley, K, Magill, L, Tinkler-Hundal, E, Southward, K, Seymour, M, Kerr, D, Gray, R, Quirke, P, QUASAR trial collaborators
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Histopathology. 72(3)
ISSN: 1365-2559
0309-0167
Popis: INTRODUCTION: The biological importance of tumour-associated stroma is increasingly apparent, yet clinical utility remains ill-defined. In stage-II / Dukes B colorectal cancer (CRC), clinical biomarkers are urgently required to direct therapeutic options. We report here prognostic/predictive analyses, and molecular associations, of stromal morphometric quantification in the Quick and Simple and Reliable (QUASAR) trial of CRC MATERIALS AND METHODS: Relative proportions of tumour epithelium (PoT) or stroma (PoS) were morphometrically quantified using digitised haematoxylin and eosin sections derived from 1,800 patients enrolled in QUASAR which randomised 3,239 (91% stage II) CRC patients between adjuvant fluorouracil/folinic acid (FUFA) chemotherapy and observation. The prognostic/predictive value of PoT/PoS measures were determined by stratified log-rank analyses RESULTS: High tumour stroma (≥50%) was associated with increased recurrence risk: 31.3% (143/457) recurrence for ≥50% versus 21.9% (294/1,343) if DISCUSSION: Simple digital morphometry applied to a single representative H&E section identifies CRC patients with over 50% higher risk of disease recurrence. This technique can reliably partition patients into sub-populations with differential risks of tumour recurrence in a simple and cost-effective manner. Further prospective validation is warranted. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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