Concurrent infection withHeligmosomoides polygyrussuppresses anti-Plasmodium yoeliiprotection partially by induction of CD4+CD25+Foxp3+Treg in mice
Autor: | Kunisuke Himeno, Kohhei Tetsutani, Kenji Ishiwata, Motomi Torii, Hajime Hisaeda, Liping Tu, Hidekazu Ishida, Shinjiro Hamano |
---|---|
Rok vydání: | 2009 |
Předmět: |
Male
Erythrocytes Regulatory T cell Immunology Cell Count chemical and pharmacologic phenomena Spleen Lymphocyte Activation Parasitemia T-Lymphocytes Regulatory Lymphocyte Depletion Interferon-gamma Mice Immune system Immunity parasitic diseases Concanavalin A Immune Tolerance medicine Animals Immunology and Allergy Strongylida Infections Mice Inbred ICR Nematospiroides dubius biology Interleukin-2 Receptor alpha Subunit Antibodies Monoclonal Forkhead Transcription Factors Dendritic Cells Plasmodium yoelii biology.organism_classification Acquired immune system medicine.disease Survival Analysis Malaria Mice Inbred C57BL medicine.anatomical_structure Antigens Helminth Immunoglobulin G Heligmosomoides polygyrus |
Zdroj: | European Journal of Immunology. 39:2822-2830 |
ISSN: | 1521-4141 0014-2980 |
Popis: | Malaria and intestinal nematode infection are widespread and co-infection frequently occurs. We investigated whether co-infected intestinal nematodes modulate immunity against co-existing malaria parasites. Infection of C57BL/6 mice with Plasmodium yoelii 17XNL (Py) was transient and self-limiting, but preceding infection with Heligmosomoides polygyrus (Hp), a mouse intestinal nematode, exacerbated malaria resulting in higher parasite burdens and poor survival of the mice. Co-infection with Hp led to reduced Py-responsive proliferation and IFN-gamma production of spleen cells, and higher activation of CD4(+)CD25(+)Foxp3(+) Treg. In vivo depletion of Treg recovered anti-Py immunity and rescued co-infected mice from exacerbated malaria. However, we did not observe any obvious ex vivo activation of Treg by either Hp products or living worms. Our results suggest that intestinal nematodes moderate host immune responses during acute malaria infection by aggressive activation of Treg. Elucidation of the mechanisms of Treg activation in situ is a target for future analyses. |
Databáze: | OpenAIRE |
Externí odkaz: |