Construction and evaluation of tumor nucleus-targeting nanocomposite for cancer dual-mode imaging - Guiding photodynamic therapy/photothermal therapy
| Autor: | Jie Zhou, Qiaolei Wang, Rui Lou, Weiran Ye, Qianwen Yin, Shizhen Geng |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
DNA damage Cell Survival Infrared Rays medicine.medical_treatment Bioengineering Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Multimodal Imaging Fluorescence Nanocomposites Biomaterials Mice Neoplasms medicine Animals Humans Viability assay chemistry.chemical_classification Cell Nucleus Reactive oxygen species Nanocomposite Singlet Oxygen Cancer Drug Synergism Hyperthermia Induced Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease Endocytosis 0104 chemical sciences medicine.anatomical_structure chemistry Photochemotherapy Mechanics of Materials Cancer research MCF-7 Cells Female Gold 0210 nano-technology Tomography X-Ray Computed Nucleus |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 102 |
| ISSN: | 1873-0191 |
| Popis: | To tackle the barrier of the insufficient intra-cellular delivery of reactive oxygen species (ROS) and heat, we designed a multifunctional nanoplatform to release ROS and heat directly in the cell nucleus for enhancing combined photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors. As a photothermal agent, WS2 nanoparticles were adsorbed photosensitive Au25(Captopril)18− (Au25) nanoclusters via electrostatic interaction. And Dexamethasone (Dex), a glucocorticoid with nucleus targeting capability, played a key role in the intra-nuclear process of heat and ROS. PTT can increase intra-tumoral blood flow to promote Au25 produce more ROS for PDT. Under near infrared (NIR) laser irradiation at a single 808 nm, these nucleus targeting WS2 nanoplatforms showed a significant decreased cell viability of 18.2 ± 1.7% and a high DNA damage degree of 59.6 ± 8.3%. Furthermore, the WS2 nanoplatform could be further used for X-ray computed tomography (CT) images. Taken together, our study provided a new prospect for effectively diagnostic and enhancing PTT/PDT efficacy. |
| Databáze: | OpenAIRE |
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