Increased levels of CD34+ cells are associated in patients with abdominal aortic aneurysms compared with patients with peripheral vascular disease
| Autor: | Kiana M. Samadzadeh, Kevin C. Chun, Eugene S. Lee, John H. Peters, Elyse N. Van Spyk |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Pathology Antigens CD34 Cell Count Gastroenterology Risk Assessment Monocytes Coronary artery disease chemistry.chemical_compound Risk Factors Internal medicine Diabetes mellitus medicine Humans Whole blood Aged Peripheral Vascular Diseases Creatinine Vascular disease business.industry Middle Aged medicine.disease Flow Cytometry Hematopoietic Stem Cells Abdominal aortic aneurysm Blood pressure chemistry Biomarker (medicine) Surgery Female business Biomarkers Aortic Aneurysm Abdominal |
| Zdroj: | The Journal of surgical research. 184(1) |
| ISSN: | 1095-8673 |
| Popis: | Background Circulating progenitor cells are integral to vascular health and effectively predict vascular reactivity. CD34 is a known marker of circulating progenitor cells. Few studies have examined the role of CD34+ cells in abdominal aortic aneurysm (AAA) disease and peripheral vascular disease (PVD). The aim of this study was to compare the percentage of CD34+ cells between patients with AAA versus PVD. Materials and methods We collected peripheral whole blood from AAA or PVD patients. The blood was stained with fluorescently labeled antibodies against CD34 or isotype controls. We collected data using a flow cytometer and analyzed them. We also recorded risk factors such as hypertension, diabetes, total cholesterol, serum white blood cells, serum creatinine, body mass index, blood pressure, statin use, current smoking status, coronary artery disease, cerebral vascular accident, and chronic obstructive pulmonary disease. Results We enrolled 24 patients in this study (AAA, n = 12; PVD, n = 12). The AAA patients had a greater percentage of CD34+ cells compared with PVD patients. (r = 0.84; P = 0.016). There were no significant risk factors differences between AAA and PVD patients. Conclusions Based on CD34+ cell counts, AAA is a less severe vascular disease than PVD. Whether CD34+ cells can serve as a biomarker for risk stratification or a potential therapy warrants further study. |
| Databáze: | OpenAIRE |
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