Polyoxygenated cyclohexene derivatives isolated from Dasymaschalon sootepense and their biological activities
| Autor: | Vichai Reutrakul, Jitra Limthongkul, Narong Nuntasaen, Pawinee Piyachaturawat, Chutima Kuhakarn, Palangpon Kongsaeree, Sakchai Hongthong, Ampai Panthong, Thaworn Jaipetch, Kanoknetr Suksen, Samran Prabpai, Surawat Jariyawat |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Anti-HIV Agents Stereochemistry Anti-Inflammatory Agents Cyclohexene Ethyl acetate Annonaceae Rats sprague dawley Rats Sprague-Dawley Mice Dasymaschalon sootepense chemistry.chemical_compound Alkaloids Flavonoid derivatives Cell Line Tumor Cyclohexenes Drug Discovery Animals Humans Organic chemistry Pharmacology Molecular Structure biology General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Rats Plant Leaves chemistry HIV-1 Reverse Transcriptase Inhibitors |
| Zdroj: | Fitoterapia. 106:158-166 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2015.09.001 |
| Popis: | Six new naturally occurring polyoxygenated cyclohexene derivatives together with eight related known derivatives, two known alkaloids, and two known flavonoid derivatives were isolated from bioassay-guided fractionation of the ethyl acetate extract of the leaves and twigs of Dasymaschalon sootepense. The structure elucidation and determination of absolute configurations were established by various spectroscopic methods, X-ray diffraction techniques as well as comparison with the literature data. Several isolated compounds were evaluated for their cytotoxic, anti-HIV-1 RT and anti-inflammatory activities. |
| Databáze: | OpenAIRE |
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