Neuropsychological Effects of Konzo: A Neuromotor Disease Associated With Poorly Processed Cassava
| Autor: | Guy Makila Mabe Bumoko, Connie Page, Michael J. Boivin, Daniel Okitundu, Dieudonné Mumba, Thorkild Tylleskär, Marie Therese Sombo, Jean Jacques Muyembe, Desire Tshala-Katumbay |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Manihot Adolescent Food Handling Disease Neuropsychological Tests Audiology Severity of Illness Index Article Cognition Memory Severity of illness medicine Humans Neuroepidemiology Motor Neuron Disease Child Subclinical infection Konzo business.industry Kaufman Assessment Battery for Children Neuropsychology medicine.disease Diet Logistic Models Motor Skills Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Democratic Republic of the Congo Female business Neurocognitive |
| Zdroj: | Pediatrics. 131:e1231-e1239 |
| ISSN: | 1098-4275 0031-4005 |
| Popis: | BACKGROUND: Konzo is an irreversible upper-motor neuron disorder affecting children dependent on bitter cassava for food. Although the neuroepidemiology of konzo is well characterized, we report the first neuropsychological findings. METHOD: Children with konzo in the Democratic Republic of Congo (mean age 8.7 years) were compared with children without konzo (mean age 9.1 years) on the Kaufman Assessment Battery for Children, second edition (KABC-II), and the Bruininks-Oseretsky Test of Motor Proficiency, second edition (BOT-2). Both groups were also compared with normative KABC measures from earlier studies in a nearby nonkonzo region. RESULTS: Using a Kruskal-Wallis test, children with konzo did worse on the KABC-II simultaneous processing (visual-spatial analysis) (K [1] = 8.78, P = .003) and mental processing index (MPI) (K [1] = 4.56, P = .03) than children without konzo. Both konzo and nonkonzo groups had poorer KABC sequential processing (memory) and MPI relative to the normative group from a nonkonzo region (K [2] = 75.55, P < .001). Children with konzo were lower on BOT-2 total (K [1] = 83.26, P < .001). KABC-II MPI and BOT-2 total were predictive of konzo status in a binary logistic regression model: odds ratio = 1.41, P < .013; 95% confidence interval 1.13–1.69. CONCLUSIONS: Motor proficiency is dramatically affected, and both children with and without konzo have impaired neurocognition compared with control children from a nonoutbreak area. This may evidence a subclinical neurocognitive form of the disease, extending the human burden of konzo with dramatic public health implications. |
| Databáze: | OpenAIRE |
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