Establishment of a tumor neovascularization animal model with biomaterials in rabbit corneal pouch
| Autor: | Hong-Chuan Li, Yang Xia, Ling Ma, Yu-Ping Chu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty genetic structures Alginates Biocompatible Materials General Biochemistry Genetics and Molecular Biology Cornea Neovascularization 03 medical and health sciences 0302 clinical medicine Animal model Glucuronic Acid medicine Animals Humans General Pharmacology Toxicology and Pharmaceutics Zebrafish Neovascularization Pathologic biology business.industry Hexuronic Acids Rabbit (nuclear engineering) General Medicine biology.organism_classification eye diseases Disease Models Animal 030104 developmental biology Regional Blood Flow 030220 oncology & carcinogenesis Cancer cell MCF-7 Cells Gelatin Rabbits sense organs Pouch Cancer cell lines medicine.symptom business Human breast Neoplasm Transplantation |
| Zdroj: | Life Sciences. 202:98-102 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2018.03.043 |
| Popis: | Aims The present animal model of tumor neovascularization most often used by researchers is zebrafish. For studies on human breast cancer cell neovascularization, a new animal model was established to enable a more convenient study of tumor neovascularization. Main methods A sodium alginate-gelatin blend gel system was used to design the new animal model. The model was established using rabbit corneal pouch implantation. Then, the animal model was validated by human breast cancer cell lines MCF-7-Kindlin-2 and MCF-7-CMV. Key findings The experiment intuitively observed the relationship between tumor and neovascularization, and demonstrated the advantages of this animal model in the study of tumor neovascularization. Significance The use of sodium alginate-gelatin blends to establish tumor neovascularization in a rabbit corneal pouch is a novel and ideal method for the study of neovascularization. It may be a better animal model for expanding the research in this area. |
| Databáze: | OpenAIRE |
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