Oxazolidinones: a new class of antibacterials
| Autor: | W G Tarpley, C W Ford, G E Zurenko, D L Shinabarger, J K Gibson, P A Aristoff |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pharmacology
medicine.drug_class Antibiotics Bacterial Infections Microbial Sensitivity Tests Biology Microbiology chemistry.chemical_compound Minimum inhibitory concentration Anti-Infective Agents chemistry Mechanism of action Pharmacokinetics In vivo Pharmacodynamics Drug Discovery Linezolid Oral route medicine Animals Humans medicine.symptom Oxazolidinones |
| Zdroj: | Current Opinion in Pharmacology. 1:470-476 |
| ISSN: | 1471-4892 |
| DOI: | 10.1016/s1471-4892(01)00082-0 |
| Popis: | The oxazolidinones represent the first truly new class of antibacterial agents to reach the marketplace in several decades. They have a unique mechanism of action involving inhibition of the initiation step of protein synthesis and are not cross-resistant to other classes of antibiotics. The first marketed member of that class, linezolid (Zyvox), shows good efficacy with an impressive antibacterial spectrum (including activity against gram-positive organisms resistant to other drugs), and a pharmacodynamic/pharmacokinetic relationship best characterized by time above the minimum inhibitory concentration. The agent is effective by both the intravenous and oral route of administration. Although technically classified as bacteriostatic against a number of pathogens in vitro, linezolid behaves in vivo like a bactericidal antibiotic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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