The complexity of nanoparticle dissolution and its importance in nanotoxicological studies
| Autor: | Samuel N. Luoma, Superb K. Misra, Agnieszka Dybowska, Deborah Berhanu, Eugenia Valsami-Jones |
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| Rok vydání: | 2012 |
| Předmět: |
inorganic chemicals
Environmental Engineering Surface Properties Nanoparticle Nanotechnology 02 engineering and technology 010501 environmental sciences Biological effect 01 natural sciences mental disorders Environmental Chemistry Particle Size Solubility Waste Management and Disposal Dissolution health care economics and organizations 0105 earth and related environmental sciences Potential impact Chemistry technology industry and agriculture Membrane Transport Proteins Biological Transport respiratory system 021001 nanoscience & nanotechnology Pollution Nanotoxicology Nanoparticles 0210 nano-technology |
| Zdroj: | Science of The Total Environment. 438:225-232 |
| ISSN: | 0048-9697 |
| DOI: | 10.1016/j.scitotenv.2012.08.066 |
| Popis: | Dissolution of nanoparticles (NPs) is an important property that alters their abundance and is often a critical step in determining safety of nanoparticles. The dissolution status of the NPs in exposure media (i.e. whether they remain in particulate form or dissolve - and to what extent), strongly affects the uptake pathway, toxicity mechanisms and the environmental compartment in which NPs will have the highest potential impact. A review of available dissolution data on NPs demonstrates there is a range of potential outcomes depending on the NPs and the exposure media. For example two nominally identical nanoparticles, in terms of size and composition, could have totally different dissolution behaviours, subject to different surface modifications. Therefore, it is imperative that toxicological studies are conducted in conjunction with dissolution of NPs to establish the true biological effect of NPs and hence, assist in their regulation. |
| Databáze: | OpenAIRE |
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