High Plasma Nonesterified Fatty Acids Are Predictive of Cancer Mortality but Not of Coronary Heart Disease Mortality: Results from the Paris Prospective Study
| Autor: | Jean-Roger Claude, Jean-Michel Warnet, G. E. Rosselin, Pierre Ducimetière, Eveline Eschwège, N Thibult, Annick Fontbonne, Marie-Aline Charles |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Risk Paris medicine.medical_specialty Epidemiology Coronary Disease Fatty Acids Nonesterified Gastroenterology chemistry.chemical_compound NEFA Neoplasms Internal medicine Heart rate Confidence Intervals medicine Humans Prospective Studies Prospective cohort study Analysis of Variance Anthropometry Triglyceride Cholesterol business.industry Mortality rate Fasting Middle Aged Prognosis Survival Rate Blood pressure Endocrinology chemistry business Body mass index Biomarkers |
| Zdroj: | American Journal of Epidemiology. 153:292-298 |
| ISSN: | 1476-6256 0002-9262 |
| Popis: | To assess the association of fasting plasma nonesterified fatty acid (NEFA) concentration with the risk of death from coronary heart disease and cancer, the authors computed 15-year mortality rates for the 4,589 working men aged 43-53 years who were included in the Paris Prospective Study between 1967 and 1972. A total of 251 and 126 men died from cancer and coronary heart disease, respectively. For coronary heart disease death, the age- and tobacco-adjusted relative risk for men in the highest 20% of the fasting plasma NEFA concentrations compared with those in the lowest 80% was 1.54 (95% confidence interval (CI): 1.01, 2.34). It became nonsignificant after further adjustment for blood pressure, iliac/thigh ratio, and plasma insulin and cholesterol concentrations. In contrast, a high fasting plasma NEFA concentration exhibited a strong independent relation with cancer mortality (relative risk = 1.66, 95% CI: 1.25, 2.21, after adjustment for age, cigarette consumption, heart rate, and body mass index). Despite pathophysiologic mechanisms linking NEFA metabolism with visceral fat and plasma glucose, insulin, and triglyceride concentrations, the plasma NEFA concentration does not appear to be a good marker for coronary heart disease risk. In contrast, an unexpected association with cancer mortality was found that may point to the need for further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|