A Diagnostic Test for Ménière's Disease and Cochlear Hydrops: Impaired High-Pass Noise Masking of Auditory Brainstem Responses
| Autor: | Chiemi Tanaka, Betty Kwong, Manuel Don |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Cochlear Diseases Hearing loss Audiology Sensitivity and Specificity Vertigo Evoked Potentials Auditory Brain Stem otorhinolaryngologic diseases Humans Medicine Endolymphatic Hydrops Inner ear Endolymphatic hydrops Meniere Disease Aged Auditory masking biology business.industry Middle Aged biology.organism_classification medicine.disease Sensory Systems Basilar membrane medicine.anatomical_structure Acoustic Stimulation Otorhinolaryngology Case-Control Studies Female sense organs Neurology (clinical) medicine.symptom Noise business Perceptual Masking Tinnitus Meniere's disease |
| Zdroj: | Otology & Neurotology. 26:711-722 |
| ISSN: | 1531-7129 |
| DOI: | 10.1097/01.mao.0000169042.25734.97 |
| Popis: | HYPOTHESIS Endolymphatic hydrops in patients diagnosed with Meniere's disease causes changes in the response properties of the basilar membrane that lead to impaired high-pass noise masking of auditory brainstem responses to clicks. BACKGROUND Meniere's disease is defined as the idiopathic syndrome of endolymphatic (cochlear) hydrops, which is an abnormal increase in the volume of cochlear fluid (endolymph) in the inner ear. Accurate detection and diagnosis are important but difficult because of the lack of sufficiently sensitive tests. METHODS Two populations were compared: (1) 38 non-Meniere's normal-hearing subjects; and (2) 23 patients who, at the time of testing, continued to have at least three of the four hallmark symptoms (i.e., tinnitus, vertigo, fluctuating hearing loss, and fullness) used in the diagnosis of Meniere's disease. Auditory brainstem responses to clicks presented ipsilaterally with masking noise that was high-pass filtered at various frequencies were recorded. RESULTS In the Meniere's patients, the masking noise is insufficient such that an undermasked Wave V is still present at a latency similar to that of Wave V in the response to the clicks alone. In the control non-Meniere's normal-hearing subjects, this undermasked component was either absent or significantly delayed because of the masking noise. The difference in the delays between these populations is such that the distributions do not overlap, resulting in 100% sensitivity and 100% specificity. CONCLUSION This test is able to distinguish objectively active Meniere's disease in individuals and may show promise for tracking changes in the severity of the disease caused by progression or treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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