Image analysis of stage 1 melanoma (1.00-2.50 mm): lymphocytic infiltrates related to metastasis and survival
| Autor: | Abdul-Ghani Kibbi, G. C. Pastorfide, Arthur J. Sober, Raymond L. Barnhill, A. L. Roa, Byers Hr, Martin C. Mihm |
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| Rok vydání: | 1992 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Skin Neoplasms Tumor-infiltrating lymphocytes business.industry Delayed time Melanoma Lymphocyte Significant difference Dermatology medicine.disease Prognosis Pathology and Forensic Medicine Metastasis Lymphocytic Infiltrate medicine.anatomical_structure Lymphocytes Tumor-Infiltrating medicine Image Processing Computer-Assisted Humans Regression Analysis Stage (cooking) business |
| Zdroj: | Journal of cutaneous pathology. 19(5) |
| ISSN: | 0303-6987 |
| Popis: | Image analysis of histologic sections of 11 patients with clinical Stage 1 melanoma, 1.00 mm-2.50 mm, who developed metastasis, was done to determine the significance of lymphocytic infiltrates relative to metastasis and survival. An age, sex, site, and thickness matched control group of non-metastasizing clinical Stage 1 melanoma revealed no significant difference in the lymphocytic infiltrate parameters from the metastasizing group with the exception of the ratio of lymphocyte infiltrate width to the tumor width (p = 0.003). Increased lymphocytic infiltrates within the tumor and subjacent to its base significantly correlated with delayed time to metastasis (p = 0.014 and p < 0.001, respectively) and longer survival period (p = 0.045 and p < 0.001, respectively). Lymphocytic infiltrate area at the tumor base in relation to tumor area was of prognostic value: the larger the ratio, the greater the time interval from metastasis to death (p = 0.008). |
| Databáze: | OpenAIRE |
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