'Just a spoonful of sugar...': import of sialic acid across bacterial cell membranes
| Autor: | Weixiao Yuan Wahlgren, Rachel A. North, S. Ramaswamy, Christopher R Horne, Daniela M. Remus, James S Davies, Renwick C. J. Dobson, Rosmarie Friemann, Andrew C. Muscroft-Taylor, Parveen Goyal |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification biology Glycoconjugate 030106 microbiology Cell Biophysics Membrane biology ATP-binding cassette transporter Review biology.organism_classification Bacterial cell structure Sialic acid carbohydrates (lipids) 03 medical and health sciences chemistry.chemical_compound medicine.anatomical_structure Membrane Biochemistry chemistry Structural Biology medicine Molecular Biology Bacteria |
| Zdroj: | Biophysical reviews. 10(2) |
| ISSN: | 1867-2450 |
| Popis: | Eukaryotic cell surfaces are decorated with a complex array of glycoconjugates that are usually capped with sialic acids, a large family of over 50 structurally distinct nine-carbon amino sugars, the most common member of which is N-acetylneuraminic acid. Once made available through the action of neuraminidases, bacterial pathogens and commensals utilise host-derived sialic acid by degrading it for energy or repurposing the sialic acid onto their own cell surface to camouflage the bacterium from the immune system. A functional sialic acid transporter has been shown to be essential for the uptake of sialic acid in a range of human bacterial pathogens and important for host colonisation and persistence. Here, we review the state-of-play in the field with respect to the molecular mechanisms by which these bio-nanomachines transport sialic acids across bacterial cell membranes. |
| Databáze: | OpenAIRE |
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