Influence of Iron on Proliferation and Cell Cycle Kinetics on Cultured Malignant and Nonmalignant Cells
| Autor: | I Flajsig, M Poljak-Blazi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Cancer Research
Bone Marrow Cells Biology Ferric Compounds KB Cells Flow cytometry Normal cell Ferric-sorbitol-citrate Bone Marrow Tumor Cells Cultured medicine Animals Humans Insulin Sorbitol Malignant cells Vero Cells Cells Cultured medicine.diagnostic_test DNA synthesis Cell Cycle General Medicine Cell cycle Flow Cytometry Cell biology iron cell cycle malignant cell Oncology Cell Cycle Kinetics Vero cell Cell Division |
| Zdroj: | Oncology. 47:443-446 |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000226866 |
| Popis: | The presence of an iron-containing complex (FSC, ferric sorbitol citrate) in medium inhibited proliferation of malignant (KB. GHC) cells: but did not appreciably alter the proliferation of normal (HBS, Vero) cells. Flow cytometric analysis showed considerable differences of malignant and normal cell growth kinetics. With addition of 200 microM Fe in FSC, malignant cell proliferation was suppressed. An increased number of cells in G1 and early S phase suggested that iron excess blocked the cell cycle before beginning of DNA synthesis. |
| Databáze: | OpenAIRE |
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