Correlation of Survival from Murine Cytomegalovirus Infection with Spleen Cell Responsiveness to Concanavallin A
| Autor: | E. F. Wheelock, Booss J |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Erythrocytes
T-Lymphocytes Congenital cytomegalovirus infection Cytomegalovirus Weanling Stimulation Spleen Viral Plaque Assay Biology Asymptomatic General Biochemistry Genetics and Molecular Biology Mice Immune system stomatognathic system Antigen Concanavalin A medicine Animals Antigens Virus quantification Sheep Age Factors virus diseases medicine.disease medicine.anatomical_structure Mice Inbred DBA Virus Diseases Immunology Female medicine.symptom Injections Intraperitoneal |
| Zdroj: | Experimental Biology and Medicine. 149:443-446 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-149-38824 |
| Popis: | Spleen cells from nonlethally MCMV-infected weanling and adult DBA/2 mice had diminished responses to Con A stimulation. In contrast, only lethal MCMV infections were associated with a complete suppression of the Con A response. The immune response to SRBC was depressed even in asymptomatic infections of weanling and adult mice. A marked maturation of resistance to the lethal effects of MCMV infection was found to occur during the fourth week of life. |
| Databáze: | OpenAIRE |
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