The effects of a new antidiabetic glycinium [(pyridine-2, 6-dicarboxylato) oxovanadate (V)] complex in high-fat diet of streptozotocin-induced diabetic rats
| Autor: | Khaled Ghasemi, Farzaneh Khadem Sameni, Mohammad Hashemi, Gholamreza Komeili, Ali Reza Rezvani, Fatemeh Ghasemi |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Pyridines Physiology 030209 endocrinology & metabolism Type 2 diabetes Diet High-Fat Streptozocin Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Diabetes mellitus Internal medicine Pyridine medicine Animals Hypoglycemic Agents Plant Extracts Chemistry High fat diet General Medicine medicine.disease Streptozotocin Rats Metformin Endocrinology Diabetes Mellitus Type 2 030220 oncology & carcinogenesis medicine.drug |
| Zdroj: | Archives of Physiology and Biochemistry. 128:80-86 |
| ISSN: | 1744-4160 1381-3455 |
| Popis: | The present study aimed to evaluate the antidiabetic effects of glycinium [(pyridine-2, 6-dicarboxylato) oxovanadate (V)] complex in type 2 diabetes rat model.Rats were allocated into 6 groups. Group I, nondiabetic rats; Group II, diabetic rats; Group III, diabetic rats receiving an intraperitoneal (i.p.) injection of metformin (45 mg/kg); Groups IV, V and VI were diabetic rats receiving i.p. injection of 5, 10, and 20 mg/kg of the complex for 3 weeks, respectively. Fasting blood glucose (FBG), insulin, liver enzymes, malondialdehyde (MDA), total antioxidant capacity (TAC), lipid profile, and HbA1c were measured.AST, ALT and GGT activities and MDA levels were increased, while TAC was decreased in diabetic animals. Treatment of diabetic rats improved the HOMA-IR and returned HbA1c level to the normal value as well as elevated TAC and reduced MDA level.We found that the complex possesses antidiabetic properties in experimental diabetes. |
| Databáze: | OpenAIRE |
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