Central Nervous System Activation following Peripheral Chemical Sympathectomy: Implications for Neural–Immune Interactions

Autor: Tracy A. Callahan, Diane T. Piekut, Jan A. Moynihan
Rok vydání: 1998
Předmět:
Male
Hypothalamo-Hypophyseal System
endocrine system
medicine.medical_specialty
Vasopressin
Sympathetic nervous system
Sympathetic Nervous System
Tyrosine 3-Monooxygenase
Corticotropin-Releasing Hormone
Neuroimmunomodulation
Immunology
Central nervous system
Pituitary-Adrenal System
Biology
Mice
Norepinephrine
Behavioral Neuroscience
Prosencephalon
Immune system
Adrenocorticotropic Hormone
Internal medicine
medicine
Animals
Sympathectomy
Oxidopamine
Brain Chemistry
Denervation
Tyrosine hydroxylase
Endocrine and Autonomic Systems
Arcuate Nucleus of Hypothalamus
Olfactory Bulb
Arginine Vasopressin
Mice
Inbred C57BL
medicine.anatomical_structure
Endocrinology
Hypothalamus
Sympatholytics
Proto-Oncogene Proteins c-fos
Nucleus
Neuroscience
Spleen
hormones
hormone substitutes
and hormone antagonists
Zdroj: Brain, Behavior, and Immunity. 12:230-241
ISSN: 0889-1591
DOI: 10.1006/brbi.1998.0526
Popis: Many studies have demonstrated that ablation of the sympathetic nervous system (SNS) alters subsequent immune responses. Researchers have presumed that the altered immune responses are predominantly the result of the peripheral phenomenon of denervation. We, however, hypothesized that chemical sympathectomy will signal and activate the central nervous system (CNS). Activation of the CNS was determined by immunocytochemical visualization of Fos protein in brains from male C57BL/6 mice at 8, 24, and 48 h following denervation. A dramatic induction of Fos protein was found in the paraventricular nucleus (PVN) of the hypothalamus and other specific brain regions at 8 and 24 h compared to vehicle control mice. Dual-antigen labeling demonstrates that corticotrophin releasing factor (CRF)-containing neurons in the PVN are activated by chemical sympathectomy; however, neurons containing neurotransmitters which may modulate CRF neurons, such as vasopressin, tyrosine hydroxylase, and adrenocorticotropin, do not coexpress Fos. Our findings suggest an involvement of the CNS in sympathectomy-induced alterations of immunity.
Databáze: OpenAIRE
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