Mortality and Comorbidity Profiles of Patients with Bullous Pemphigoid in Korea
| Autor: | Sook Jung Yun, Jee-Bum Lee, Hyeon Woo Jeon, Young Ho Won, Seung-Chul Lee |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Population Dermatology Disease Comorbidity 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Dementia Mortality education Stroke education.field_of_study business.industry Bullous pemphigoid Mortality rate medicine.disease Standardized mortality ratio Risk factors 030220 oncology & carcinogenesis Original Article business |
| Zdroj: | Annals of Dermatology |
| ISSN: | 1013-9087 |
| Popis: | Background: Bullous pemphigoid (BP) is a common autoimmune- mediated blistering skin disease that is significantly associated with mortality and morbidity. However, few studies regarding the mortality and comorbidity profiles of BP have been reported in Korea. Objective: To evaluate and compare the mortality, comorbidity profiles, and risk factors between patients with BP who visited our clinic and an age-matched general population of Korea. Methods: We retrospectively evaluated 103 patients diagnosed with BP between 2006 and 2013 at Chonnam National University Hospital in Gwangju, Korea. Results: The 1-year, 2-year, and 5-year mortality rates of the patients were 18.44%, 28.16%, and 42.00%, respectively. The median age was 76 years (range, 41∼96 years). The standardized mortality ratio of patients with BP was 1.83 times that of the age- and sex-matched general population of Korea. Old age at the time of diagnosis, cardiac disease and renal disease were associated with increased 5-year mortality. In addition, the prevalence of diabetes, stroke, dementia, and Parkinson’s disease was higher among BP patients than in the general population. Conclusion: The mortality rate of patients with BP is higher than that of the general Korean population. Korean patients with BP are more likely to have dementia, Parkinson’s disease, diabetes, and stroke. Risk factors for increased 5-year mortality include old age at the time of diagnosis and medical comorbidities, especially cardiac disease and renal disease. (Ann Dermatol 30(1) 13∼19, 2018) |
| Databáze: | OpenAIRE |
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