Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions
| Autor: | Udo Oppermann, B De Leo, G Steers, F E Martinez, Thomas T. Tapmeier, Thomas M. Zollner, Nilufer Rahmioglu, J Mueller, Benedikt M. Kessler, Andreas Steinmeyer, Krina T. Zondervan, Sanjiv Manek, B Elger, Holger Hess-Stumpp, Catherine Shang, Stephanie G. Dakin, Stephen Kennedy, Philip D. Charles, Oliver Fischer, Karl J. Morten, Cemsel Bafligil, Christian M. Becker, Thezenas M-L., Alexis Laux-Biehlmann |
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| Rok vydání: | 2020 |
| Předmět: |
endometriosis
0301 basic medicine AOC3 Endometriosis lcsh:Medicine Peritoneal Diseases medicine.disease_cause Mice 0302 clinical medicine Myeloid Cells lcsh:Science chemistry.chemical_classification Analgesics Mice Inbred BALB C Sulfonamides 030219 obstetrics & reproductive medicine Multidisciplinary Manchester Cancer Research Centre Interleukin Chronic inflammation 3. Good health Allyl Compounds medicine.anatomical_structure Methionine sulfoxide reductase Female Amine Oxidase (Copper-Containing) Inflammation Mediators Metabolic Networks and Pathways Amine oxidase Iron Heme Article 03 medical and health sciences Peritoneal cavity Phagocytosis medicine Animals Humans Author Correction Aldehydes Reactive oxygen species business.industry Gene Expression Profiling ResearchInstitutes_Networks_Beacons/mcrc Interleukin-8 lcsh:R medicine.disease Disease Models Animal Oxidative Stress 030104 developmental biology chemistry Infertility Cancer research lcsh:Q Lipid Peroxidation business Cell Adhesion Molecules Biomarkers Oxidative stress |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports Thézénas, M-L, De Leo, B, Laux-Biehlmann, A, Bafligil, C, Elger, B, Tapmeier, T, Morten, K, Rahmioglu, N, Dakin, S G, Charles, P, Martinez, F E, Steers, G, Fischer, O M, Mueller, J, Hess-Stumpp, H, Steinmeyer, A, Manek, S, Zondervan, K T, Kennedy, S, Becker, C M, Shang, C, Zollner, T M, Kessler, B M & Oppermann, U 2020, ' Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions ', Scientific Reports, vol. 10, no. 1, pp. 1495 . https://doi.org/10.1038/s41598-020-58362-3 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-58362-3 |
| Popis: | Endometriosis is a common gynaecological disease of women in reproductive age, and is thought to arise from retrograde menstruation and implantation of endometrial tissue, mostly into the peritoneal cavity. The condition is characterized by a chronic, unresolved inflammatory process thereby contributing to pain as cardinal symptom in endometriosis. Elevated reactive oxygen species (ROS) and oxidative stress have been postulated as factors in endometriosis pathogenesis. We here set out for a systematic study to identify novel mechanisms and pathways relating to oxidative stress in ectopic peritoneal lesions. Using combined proteomic and transcriptomic approaches, we identified novel targets including upregulated pro-oxidative enzymes, such as amine oxidase 3/vascular adhesion protein 1 (AOC3/VAP1) as well as downregulated protective factors, in particular alkenal reductase PTGR1 and methionine sulfoxide reductase. Consistent with an altered ROS landscape, we observed hemoglobin / iron overload, ROS production and lipid peroxidation in ectopic lesions. ROS-derived 4-hydroxy-2-nonenal induced interleukin IL-8 release from monocytes. Notably, AOC3 inhibitors provoked analgesic effects in inflammatory pain models in vivo, suggesting potential translational applicability. |
| Databáze: | OpenAIRE |
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