Replacing 30 Gy in 10 fractions with stereotactic body radiation therapy for bone metastases: A large multi-site single institution experience 2016–2018
| Autor: | T. Jonathan Yang, Oren Cahlon, N.A. Wijetunga, Kaitlyn Lapen, C. Jillian Tsai, Marisa A. Kollmeier, A.J. Xu, Diana G. Wang, Divya Yerramilli, Josh Yamada, Gerri Pastrana, Adam M. Schmitt, Erin F. Gillespie, Max Vaynrub, Daniel S. Higginson, Ernesto Santos Martin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Palliative care medicine.medical_treatment R895-920 SBRT stereotactic body radiation therapy Logistic regression Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine medicine Outpatient clinic Radiology Nuclear Medicine and imaging Single institution KPS Karnofsky Performance Scale RC254-282 Performance status business.industry Bone metastases Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RT radiation therapy medicine.disease ASTRO American Society for Radiation Oncology Radiation therapy Regimen Oncology Stereotactic body radiation therapy 030220 oncology & carcinogenesis Radiology business End-of-life |
| Zdroj: | Clinical and Translational Radiation Oncology, Vol 25, Iss, Pp 75-80 (2020) Clinical and Translational Radiation Oncology |
| ISSN: | 2405-6308 |
| Popis: | Highlights • Contemporary trends in radiation technique and fractionation for bone metastases at a large academic center with a specialized metastatic program. • Stereotactic body radiation therapy (SBRT) is replacing long-course conventional RT for bone metastases. • Complexity of RT is increasing, particularly in the community-based regional clinic setting. • Single-fraction conventional RT is preferentially employed at the end of life, but prognostic algorithms are needed to further optimize use. Background Bone metastases cause significant morbidity in patients with cancer, and radiation therapy (RT) is an effective treatment approach. Indications for more complex ablative techniques are emerging. We sought to evaluate RT trends at a large multi-site tertiary cancer center. Methods Patients who received RT for bone metastases at a single institution (including regional outpatient clinics) from 2016 to 2018 were identified. Patients were grouped by RT regimen: single-fraction conventional RT (8 Gy × 1), 30 Gy in 10 fractions, SBRT, and “other”. Multinomial logistic regression was performed to assess trends in regimens over time. Binary logistic regression was performed to evaluate factors associated with receipt of SBRT. Results Between 2016 and 2018, 5,952 RT episodes were received by 2,969 patients with bone metastases. Overall, 76% of episodes were ≤ 5 fractions. The median number of fractions planned for SBRT and non-SBRT episodes was 3 (IQR 3–3) and 5 (IQR 5–10), respectively. Use of SBRT increased from 2016 to 2018 (39% to 53%, p |
| Databáze: | OpenAIRE |
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