Antihypertensive effectiveness of the nifedipine gastrointestinal therapeutic system
| Autor: | Robert L. Reeves, R A Mulinari, Bruce Garrett, James T. Higgins, James Crook, Alan K. Halperin, Irene Gavras, Edward T. Zawada, Haralambos Gavras |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Nifedipine Sitting Essential hypertension Placebo Hydrochlorothiazide Double-Blind Method Multicenter trial medicine Humans Multicenter Studies as Topic Aged Clinical Trials as Topic business.industry General Medicine Middle Aged Placebo period medicine.disease Nifedipine gits Intestinal Absorption Delayed-Action Preparations Anesthesia Hypertension Drug Evaluation Female business medicine.drug |
| Zdroj: | The American Journal of Medicine. 83:20-23 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(87)90632-2 |
| Popis: | The results of a multicenter trial conducted in order to determine the therapeutic efficacy of the gastrointestinal therapeutic system (GITS) formulation of nifedipine in comparison with hydrochlorothiazide and placebo in the management of mild to moderate essential hypertension are presented. During a one-week wash-out phase, antihypertensive therapy was discontinued in all patients. After a three-week single-blind placebo period, eligible patients were randomly assigned in a double-blind fashion to one of three treatment groups for a one-week titration period and a nine-week efficacy period. Patients received either nifedipine GITS, 30 or 60 mg daily; hydrochlorothiazide, 25 or 50 mg daily; or placebo. Sitting and standing blood pressures decreased by an average 11.6/10.4 and 10.8/10.8 mm Hg, respectively, with nifedipine GITS therapy, and 14.8/10.8 and 14.3/8.2 mm Hg, respectively, with hydrochlorothiazide therapy. Compared with placebo, these changes were highly significant for both sitting (p less than or equal to 0.005) and standing (p less than or equal to 0.02) measurements. Heart rate remained essentially unchanged in all three groups. It was therefore concluded that monotherapy with nifedipine GITS, at doses of 30 or 60 mg given once daily, effectively reduces blood pressure in patients with hypertension to a degree comparable with that seen in hydrochlorothiazide therapy. |
| Databáze: | OpenAIRE |
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