Extracellular influences on tumour angiogenesis in the aged host
| Autor: | M J Reed, Stephen R. Plymate, Cynthia C. Sprenger |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty senescence Angiogenesis medicine.medical_treatment Reviews Biology Matrix metalloproteinase Models Biological Neovascularization Extracellular matrix angiogenesis 03 medical and health sciences Prostate cancer 0302 clinical medicine growth factors medicine Extracellular Humans Neoplasms Glandular and Epithelial Aged 030304 developmental biology Aged 80 and over Extracellular Matrix Proteins 0303 health sciences Neovascularization Pathologic Growth factor Prostatic Neoplasms matrix metalloproteinases Cancer prostate cancer medicine.disease microenvironment Extracellular Matrix Oncology 030220 oncology & carcinogenesis Androgens Cancer research Intercellular Signaling Peptides and Proteins medicine.symptom Extracellular Space |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6604144 |
| Popis: | Whether tumours are epithelial or non-epithelial in origin, it is generally accepted that once they reach a certain size all solid tumours are dependent upon a vascular supply to provide nutrients. Accordingly, there is great interest in how the extracellular environment enhances or inhibits vascular growth. In this minireview, we will examine key extracellular components, their changes with ageing, and discuss how these alterations may influence the subsequent development of tumour vasculature in the aged host. Because of the tight correlation between advanced age and development of prostate cancer, we will use prostate cancer as the model throughout this review. |
| Databáze: | OpenAIRE |
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