Isolation and identification of previtamin D3 from the skin of rats exposed to ultraviolet irradiation
| Autor: | Michael F. Holick, Jane Frommer, Neil M. Richtand, John T. Potts, Stephen C. McNeill, Sally Ann Holick, John W. Henley |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Lumisterol
Ultraviolet Rays Photodissociation Previtamin D3 medicine.disease_cause Mass spectrometry Photochemistry Biochemistry Mass Spectrometry Rats chemistry.chemical_compound Kinetics chemistry Mass spectrum Vitamin D and neurology medicine Animals Cholecalciferol Ultraviolet Chromatography High Pressure Liquid Skin |
| Zdroj: | Biochemistry. 18(6) |
| ISSN: | 0006-2960 |
| Popis: | The process of the photolytic activation of vitamin D precursor(s) in the skin has been elucidated by a detailed analysis of the products formed after ultraviolet light exposure. The photolytic product isolated from the skin of rats exposed to ultraviolet irradiation was identified as previtamin D/sub 3/ by several criteria including its characteristic ultraviolet absorption spectrum, mass spectrum, and thermal isomerization to vitamin D/sub 3/, which itself was identified also by mass spectroscopy. Vitamin D/sub 3/ per se was not formed by ultraviolet irradiation-vitamin D/sub 3/ arises exclusively from the thermal conversion of previtamin D/sub 3/. Detectable amounts of lumisterol/sub 3/ or tachysterol/sub 3/ were not seen. |
| Databáze: | OpenAIRE |
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