Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment
| Autor: | Yaser A. El-Badry, Ayman A. El-Badry, Soheir Mahmoud, Wegdan Mohamed Abd El Wahab, Doaa A. Hamdy, Mohamed A. El-Badry |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Schistosoma Mansoni Physiology Eggs RC955-962 Administration Oral Pharmacology medicine.disease_cause Biochemistry Antioxidants Praziquantel Mice Animal Cells Reproductive Physiology Arctic medicine. Tropical medicine Medicine and Health Sciences Nanotechnology Public and Occupational Health Anthelmintics Antioxidant Therapy Granuloma biology Pharmaceutics Mefloquine Eukaryota 030108 mycology & parasitology Infectious Diseases Liver Granulomas Schistosoma Engineering and Technology Drug Therapy Combination Schistosoma mansoni Cellular Types Public aspects of medicine RA1-1270 Research Article medicine.drug Immune Cells Immunology Schistosomiasis Ginger 03 medical and health sciences Drug Therapy Helminths parasitic diseases medicine Animals Parasite Egg Count Prophylaxis Plant Extracts business.industry Therapeutic effect Organisms Public Health Environmental and Occupational Health Biology and Life Sciences Cell Biology medicine.disease biology.organism_classification Invertebrates Schistosomiasis mansoni 030104 developmental biology Nanoparticles Pre-Exposure Prophylaxis Preventive Medicine business Zoology Oxidative stress |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009423 (2021) PLoS Neglected Tropical Diseases |
| ISSN: | 1935-2735 1935-2727 |
| Popis: | Background Nanotechnology has been manufactured from medicinal plants to develop safe, and effective antischistosmal alternatives to replace today’s therapies. The aim of the study is to evaluate the prophylactic effect of ginger-derived nanoparticles (GNPs), and the therapeutic effect of ginger aqueous extract, and GNPs on Schistosoma mansoni (S. mansoni) infected mice compared to praziquantel (PZQ), and mefloquine (MFQ). Methodology/principal findings Eighty four mice, divided into nine different groups, were sacrificed at 6th, 8th, and 10th week post-infection (PI), with assessment of parasitological, histopathological, and oxidative stress parameters, and scanning the worms by electron microscope. As a prophylactic drug, GNPs showed slight reduction in worm burden, egg density, and granuloma size and number. As a therapeutic drug, GNPs significantly reduced worm burden (59.9%), tissue egg load (64.9%), granuloma size, and number at 10th week PI, and altered adult worm tegumental architecture, added to antioxidant effect. Interestingly, combination of GNPs with PZQ or MFQ gave almost similar or sometimes better curative effects as obtained with each drug separately. The highest therapeutic effect was obtained when ½ dose GNPs combined with ½ dose MFQ which achieved 100% reduction in both the total worm burden, and ova tissue density as early as the 6th week PI, with absence of detected eggs or tissue granuloma, and preservation of liver architecture. Conclusions/significance GNPs have a schistosomicidal, antioxidant, and hepatoprotective role. GNPs have a strong synergistic effect when combined with etiological treatments (PZQ or MFQ), and significantly reduced therapeutic doses by 50%, which may mitigate side effects and resistance to etiological drugs, a hypothesis requiring further research. We recommend extending this study to humans. Author summary Schistosomiasis is one of the most important tropical diseases that yearly causes millions of morbidities and mortalities. Several researchers are interested in trying variable chemical and herbal drugs for treating the disease. This research introduced a trial for prophylaxis and treating schistosomiasis mansoni in mice using ginger-derived nanoparticles (GNPs). GNPs have antischistosmal, antioxidant and hepatoprotective features. The nano-formulation of ginger provides a safer therapeutic and restorative enhancer to etiological treatments. GNPs may reduce infection complications, reduce required therapeutic doses of Schistosoma-standard drugs, and may help mitigate the side effects of and resistance to standard drugs; hypotheses which require further studies. |
| Databáze: | OpenAIRE |
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