Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass
Autor: | Helena Gylling, Sari Venesmaa, Dorota Kaminska, Maarit Hallikainen, Johan Auwerx, Jussi Pihlajamäki, Matti Pääkkönen, Marko Simonen, Leena Moilanen, Marjukka Kolehmainen, M. I. J. Uusitupa, Mary-Elizabeth Patti, Markku Laakso, Nassim Dali-Youcef, Pirjo Käkelä |
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Rok vydání: | 2012 |
Předmět: |
Blood Glucose
Male Endocrinology Diabetes and Metabolism Adipose tissue Body Mass Index 0302 clinical medicine Weight loss CYP27A1 Longitudinal Studies Finland 0303 health sciences Nutrition and Dietetics Bile acid Middle Aged Roux-en-Y anastomosis Obesity Morbid Glucose and lipid oxidation Treatment Outcome Adipose Tissue Liver Female medicine.symptom medicine.medical_specialty medicine.drug_class Gastric bypass Gastric Bypass 030209 endocrinology & metabolism digestive system Article Bile Acids and Salts 03 medical and health sciences Lipid oxidation Internal medicine medicine Humans 030304 developmental biology DIO2 business.industry nutritional and metabolic diseases Lipid metabolism Lipid Metabolism Bile acids Obesity surgery Glucose Endocrinology Surgery Energy Metabolism business Biomarkers |
Zdroj: | Obesity Surgery. 22:1473-1480 |
ISSN: | 1708-0428 0960-8923 |
Popis: | Laparoscopic Roux-en-Y gastric bypass (RYGB) induces a more favorable metabolic profile than expected by weight loss alone. In this study, we investigated the effect of RYGB on serum bile acid levels and their relation to clinical outcomes. We included 30 obese patients who underwent RYGB (BMI = 46.1 +/- 5.9 kg/m(2)). Clinical measurements and laboratory determinations were performed before surgery and 1 year after surgery. Fasting serum bile acids were measured by an enzymatic method and individual bile acids were quantified by HLPC-tandem mass spectrometry. Indirect calorimetry was performed to measure the rates of energy expenditure and substrate oxidation. Fasting total serum bile acid levels increased twofold after RYGB (pre, 3.68 +/- 2.03 vs. post, 7.06 +/- 9.65 mu mol/l, +92 %, p = 0.002). This increase in total bile acids was accompanied by a decrease in conjugated bile acids, which correlated with decreased glucose oxidation (r = 0.571, p = 0.002) and with increased lipid oxidation (r = -0.626, p = 0.0004). The change in taurine-conjugated bile acids correlated with altered DIO2 mRNA expression in adipose tissue (r = -0.498, p = 0.013) potentially linking bile acid conjugation to substrate oxidation through DIO2. Fasting serum bile acid levels increase after RYGB. More specifically, changes in bile acid conjugation after RYGB associate with altered energy metabolism. |
Databáze: | OpenAIRE |
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