Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

Autor: Helena Gylling, Sari Venesmaa, Dorota Kaminska, Maarit Hallikainen, Johan Auwerx, Jussi Pihlajamäki, Matti Pääkkönen, Marko Simonen, Leena Moilanen, Marjukka Kolehmainen, M. I. J. Uusitupa, Mary-Elizabeth Patti, Markku Laakso, Nassim Dali-Youcef, Pirjo Käkelä
Rok vydání: 2012
Předmět:
Blood Glucose
Male
Endocrinology
Diabetes and Metabolism
Adipose tissue
Body Mass Index
0302 clinical medicine
Weight loss
CYP27A1
Longitudinal Studies
Finland
0303 health sciences
Nutrition and Dietetics
Bile acid
Middle Aged
Roux-en-Y anastomosis
Obesity
Morbid
Glucose and lipid oxidation
Treatment Outcome
Adipose Tissue
Liver
Female
medicine.symptom
medicine.medical_specialty
medicine.drug_class
Gastric bypass
Gastric Bypass
030209 endocrinology & metabolism
digestive system
Article
Bile Acids and Salts
03 medical and health sciences
Lipid oxidation
Internal medicine
medicine
Humans
030304 developmental biology
DIO2
business.industry
nutritional and metabolic diseases
Lipid metabolism
Lipid Metabolism
Bile acids
Obesity surgery
Glucose
Endocrinology
Surgery
Energy Metabolism
business
Biomarkers
Zdroj: Obesity Surgery. 22:1473-1480
ISSN: 1708-0428
0960-8923
Popis: Laparoscopic Roux-en-Y gastric bypass (RYGB) induces a more favorable metabolic profile than expected by weight loss alone. In this study, we investigated the effect of RYGB on serum bile acid levels and their relation to clinical outcomes. We included 30 obese patients who underwent RYGB (BMI = 46.1 +/- 5.9 kg/m(2)). Clinical measurements and laboratory determinations were performed before surgery and 1 year after surgery. Fasting serum bile acids were measured by an enzymatic method and individual bile acids were quantified by HLPC-tandem mass spectrometry. Indirect calorimetry was performed to measure the rates of energy expenditure and substrate oxidation. Fasting total serum bile acid levels increased twofold after RYGB (pre, 3.68 +/- 2.03 vs. post, 7.06 +/- 9.65 mu mol/l, +92 %, p = 0.002). This increase in total bile acids was accompanied by a decrease in conjugated bile acids, which correlated with decreased glucose oxidation (r = 0.571, p = 0.002) and with increased lipid oxidation (r = -0.626, p = 0.0004). The change in taurine-conjugated bile acids correlated with altered DIO2 mRNA expression in adipose tissue (r = -0.498, p = 0.013) potentially linking bile acid conjugation to substrate oxidation through DIO2. Fasting serum bile acid levels increase after RYGB. More specifically, changes in bile acid conjugation after RYGB associate with altered energy metabolism.
Databáze: OpenAIRE
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