Cellular uptake of nanoparticles: journey inside the cell
| Autor: | Morteza Mahmoudi, Erik C. Dreaden, Alaaldin M. Alkilany, Shahed Behzadi, Majd A. Hamaly, Omid C. Farokhzad, Wei Tao, Vahid Serpooshan, Mahmoud Y. Alkawareek, Dennis Brown |
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| Rok vydání: | 2017 |
| Předmět: |
Cell signaling
Biochemical Phenomena Chemistry Cell technology industry and agriculture Nanoparticle Biological Transport Nanotechnology Cell Communication 02 engineering and technology General Chemistry Cell fate determination 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Article 0104 chemical sciences medicine.anatomical_structure medicine Humans Nanoparticles Cell structure 0210 nano-technology |
| Zdroj: | Chemical Society Reviews. 46:4218-4244 |
| ISSN: | 1460-4744 0306-0012 |
| DOI: | 10.1039/c6cs00636a |
| Popis: | Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body in myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at the cellular and subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell-cell communication, and modulate cell structure in a manner dictated largely by phenomena at the nano-bio interface. Recent advances in chemical synthesis have yielded new nanoscale materials with precisely defined biochemical features, and emerging analytical techniques have shed light on nuanced and context-dependent nano-bio interactions within cells. In this review, we provide an objective and comprehensive account of our current understanding of the cellular uptake of NPs and the underlying parameters controlling the nano-cellular interactions, along with the available analytical techniques to follow and track these processes. |
| Databáze: | OpenAIRE |
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