Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system

Autor:	Sergio C. Oliveira, Fábio V. Marinho, Mariana T.Q. de Magalhães, Luciana C. C. Leite, E. Jane Homan, Nina M. G. P. de Queiroz, Marcelo A. Chagas
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine COVID-19 Vaccines Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 030106 microbiology Immunology Computational biology Review Biology Antibodies Viral Microbiology 03 medical and health sciences Nucleic Acid Vaccines Antigen Vaccines DNA Humans BCG Vaccines SARS-CoV-2 Spike Protein RBD domain COVID-19 Viral Vaccines 030104 developmental biology Infectious Diseases Spike Glycoprotein Coronavirus BCG Vaccine Middle East Respiratory Syndrome Coronavirus Vector system Delivery system Angiotensin-Converting Enzyme 2 BCG vaccine Epitope Mapping Protein Binding
Zdroj:	Microbes and Infection
ISSN:	1286-4579
DOI:	10.1016/j.micinf.2020.09.004
Popis:	This article discusses standard and new disruptive strategies in the race to develop an anti-COVID-19 vaccine. We also included new bioinformatic data from our group mapping immunodominant epitopes and structural analysis of the spike protein. Another innovative approach reviewed here is the use of BCG vaccine as priming strategy and/or delivery system expressing SARS-CoV-2 antigens.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7f943e5080f85b121083883a5da490 Zobrazit plný text záznamu Full Text from ScienceDirect