Comparison of activities of β-lactam antibiotics against Streptococcus pneumoniae with recombinant penicillin-binding protein genes from a penicillin-resistant strain
| Autor: | Minoru Yonezawa, Takayoshi Fukushima, Takahisa Suzuki, Kumiko Maeda, Mizuyo Kurazono, Yumiko Sanbongi, Matsuhisa Inoue, Kimiko Ubukata, Takashi Ida |
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| Rok vydání: | 2005 |
| Předmět: |
Microbiology (medical)
Penicillin binding proteins medicine.drug_class Penicillin Resistance Molecular Sequence Data Cephalosporin Antibiotics Microbial Sensitivity Tests beta-Lactams medicine.disease_cause Microbiology law.invention law Streptococcus pneumoniae polycyclic compounds medicine Penicillin-Binding Proteins Pharmacology (medical) Amino Acid Sequence Gene Recombination Genetic Strain (chemistry) Chemistry Anti-Bacterial Agents Infectious Diseases Recombinant DNA Antibacterial activity |
| Zdroj: | Journal of Infection and Chemotherapy. 11:107-111 |
| ISSN: | 1341-321X |
| DOI: | 10.1007/s10156-005-0374-2 |
| Popis: | We investigated the antibacterial activities of 19 beta-lactams against three recombinant bacterial strains, in which three penicillin-binding protein genes, pbp2x, pbp1a, and pbp2b, from penicillin-resistant Streptococcus pneumoniae (PRSP), were transformed to a penicillin-susceptible strain. By the acquisition of the pbp2x gene from PRSP, the minimum inhibitory concentrations (MICs) of third-generation cephalosporins were increased more than eight fold. When the strain acquired the PRSP pbp1a gene in addition to pbp2x, the MICs of all tested beta-lactams increased 2- to 16-fold. When the strain acquired the PRSP pbp2b gene in addition to pbp2x and pbp1a, the MICs of penicillins and carbapenems increased 4- to 16-fold. However, two novel carbapenems, ME1036 and L-036, showed excellent antibacterial activities against these recombinant strains, as well as against the parent PRSP. |
| Databáze: | OpenAIRE |
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