Supplemental Figures 1-5 from Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer

Autor: Jenny C. Chang, Bhuvanesh Dave, Helen Wong, Anthony J. Kozielski, Wen Chen, Wei Qian, Wen-Feng Li, John G. Kuhn, Sergio M. Granados-Principal, Roberto R. Rosato, Dong Soon Choi, Daniel Dávila-González
Rok vydání: 2023
DOI: 10.1158/1078-0432.22463898.v1
Popis: Supplemental Figure 1. Docetaxel induce the expression of iNOS following a bell shape distribution, no consistent effect is observed on eNOS; Supplemental Figure 2. L-NMMA decreased iNOS and enhances docetaxel toxicity on MDA-MB 468; Supplemental Figure 3. Response to NOS inhibition therapy on TNBC PDXs. Supplemental Figure 4. (A) NOS inhibition mitigates pro-survival pathways activated by docetaxel; Supplemental Figure 5. NOS inhibition therapy enhance apoptotic response; Supplemental Figure 5. NOS inhibition therapy enhance apoptotic response.
Databáze: OpenAIRE