| Popis: |
This study sought to investigate the ameliorative effect of Parkia biglobosa against potassium bromate-induced oxidative stress in Wistar rats. P. biglobosa was extracted with soxhlet extractor with ethanol as the solvent. Twenty-four Wistar rats were grouped into A, B, C and D after seven days acclimatization. Group A was given distilled water orally. Animals in groups B, C and D were administered 100 mg/kg body weight of potassium bromate, but groups C and D were also treated with 100 and 200 mg/kg body weight of P. biglobosa respectively. At the end of 28 days after receiving potassium bromate and locust bean extract, the results of plasma, hepatic, renal, and cardiac oxidative stress indicators in rats are shown in Tables 1, 2, 3, and 4 respectively. The findings demonstrated that, as compared to the control group, potassium bromate caused a significant decrease (p0.05) in the plasma, hepatic, renal, and cardiac catalase, superoxide dismutase (SOD), and glutathione peroxidase activity (GPx), reduced glutathione (GSH) concentrations, and increased Malondialdehyde (MDA) levels. Rats treated with extract from locust bean seeds at doses of 100 and 200 mg/kg body weight experienced significant increases in antioxidant levels and decreases in Malondialdehyde levels in their plasma and tissues, with the findings of the 200 mg/kg dose being comparable to those seen in the control group. P. biglobosa was found to cause significant increase in antioxidant levels among the rats thereby ameliorating the oxidative damage caused by potassium bromate. |
