Measurement of blood calprotectin (MRP-8/MRP-14) levels in patients with juvenile idiopathic arthritis
| Autor: | Jaryna J. Bojko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Immunology Arthritis Gastroenterology 03 medical and health sciences 0302 clinical medicine Blood serum fluids and secretions Rheumatology Internal medicine Active phase medicine Immunology and Allergy In patient Elisa method 030203 arthritis & rheumatology Original Paper Oligoarthritis business.industry blood calprotectin biomarkers medicine.disease MRP-8/MRP-14 juvenile idiopathic arthritis Polyarthritis Calprotectin business 030215 immunology |
| Zdroj: | Reumatologia |
| ISSN: | 2084-9834 0034-6233 |
| Popis: | Objectives: The aim of the investigation was to compare blood calprotectin (MRP8/14, S100A 8/9) levels in patients with systemic-onset, polyarticular, RF-negative and oligoarticular subtypes of juvenile idiopathic arthritis (JIA), and to explore links between blood calprotectin levels and clinical and laboratory markers of JIA activity. Material and methods: Measurement of calprotectin in blood serum was performed in 160 patients with JIA followed up at Lviv Regional Council Public Institution “Western-Ukrainian Specialised Children’s Medical Centre”. Seventeen patients with systemic-onset JIA (sJIA) and 49 patients with other JIA subtypes (RF-negative polyarthritis and oligoarthritis) in the active phase of the disease were included in this study. Determination of calprotectin levels in blood serum was performed using EK-MRP8/14 Buhlmann Calprotectin reagents (Buhlmann, Switzerland) by the ELISA method. Results: The results of the investigations showed that blood calprotectin levels were higher in patients with systemic-onset subtype of the disease (median 13,800 ng/ml), and differed significantly from levels in healthy children (median 1,800 ng/ml, p = 0.00002), levels in patients with articular subtypes of JIA (median 2,700 ng/ml, p = 0.000008), and patients with RF-negative polyarthritis (median 3,800 ng/ml, p = 0.003226) and oligoarthritis (median 2,500 ng/ml, p = 0.000009). The highest blood calprotectin levels were found in patients with newly diagnosed sJIA, the median being 32,500 ng/ml (range: 13,800–177,000 ng/ml). Direct correlations were found between blood calprotectin and JADAS 27 activity score (p = 0.000009), ESR (p = 0.000079) and CRP (p = 0.000058). Conclusions: Blood calprotectin level is one of the measures that can be used to confirm the diagnosis of sJIA and to monitor the disease activity and therapy effectiveness. |
| Databáze: | OpenAIRE |
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