Fatty liver of pregnancy and its relationship to tetracycline therapy
| Autor: | Hugh A. Edmondson, John L. Peters, Constantine T. Kunelis |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
medicine.medical_specialty
Tetracycline Toxicology chemistry.chemical_compound Drug Therapy Pregnancy Internal medicine medicine Brain Diseases Pyelonephritis Ethionine medicine.diagnostic_test business.industry Stupor Fatty liver General Medicine medicine.disease Anti-Bacterial Agents Fatty Liver Pregnancy Complications Endocrinology medicine.anatomical_structure Pancreatitis chemistry Female Kidney Diseases medicine.symptom Pancreas business Liver function tests medicine.drug |
| Zdroj: | The American Journal of Medicine. 38:359-377 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(65)90145-2 |
| Popis: | The clinical, laboratory and pathologic features of sixteen patients with fatty liver of pregnancy are presented. Four of these patients survived. Twelve patients in this series were treated for acute pyelonephritis with large doses of tetracycline intravenously, but four who had not received tetracycline had hepatic lesions that were indistinguishable from those in patients with fatty liver of pregnancy. Six nonpregnant women treated with tetracycline intravenously had similar fatty changes in the liver. There was a high incidence of pathologic or functional involvement of the pancreas, kidneys and brain. Central nervous system changes are described, severe enough to be etiologically related to the stupor and coma noted in many patients with fatty liver of pregnancy who had previously received tetracycline. The similarity in morphology of fatty liver of pregnancy with that in experimental lesions produced by protein anabolism depressants, such as ethionine or essential amino acid deficient diets, is reiterated. Levels of nonesterified fatty acids in the liver, although elevated above normal, are no greater than nonesterified fatty acids in fatty livers due to other causes. The possibility exists that the liver during pregnancy is more sensitive to agents that depress protein anabolism, such as the tetracyclines. The question is also raised as to whether or not pre-existing pyelonephritis may also be a predisposing factor in the production of fatty liver of pregnancy. It is proposed that fatty liver of pregnancy be referred to as "fatty liver of pregnancy, idiopathic," or "fatty liver of pregnancy, tetracycline associated." |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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