Clinical importance of ADC in the prediction of 125I in the treatment for gliomas
| Autor: | Lili Yang, Lijing Peng, Xiaokun Hu, Congxiao Wang, Zixiang Li, Wei Zhang, Zhijian Xu, Li Xueda, Song Wang, Tao Su, Ying Luan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Multivariate analysis business.industry medicine.medical_treatment Brachytherapy Hazard ratio 125I brachytherapy medicine.disease Institutional review board Confidence interval minimum ADC Glioma Internal medicine medicine Effective diffusion coefficient Gliomas In patient business Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | Objectives: To determine whether the minimum apparent diffusion coefficient (minADC) value can stratify survival in patients with glioma before 125I brachytherapy. Methods: The study was approved by the Institutional Review Board, and the requirement for informed consent was waived. Twenty-three patients (16 male, 7 female; median age, 48 years) with high-grade glioma (HGG) (n=9) or recurrence after multimodal treatment (n=14) were included in this study. minADC values were obtained before 125I implantation. Overall survival (OS) and progression-free survival (PFS) were analyzed with Cox proportional hazards regression models and the Kaplan-Meier method with the log-rank test. Results: For 125I-treated patients, the hazard ratio for OS in patients with ADC≥1.0*10^-3 mm2·sec-1 (high minADC) versus ADC |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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