Feasibility and Therapeutic Potential of 177Lu–Fibroblast Activation Protein Inhibitor–46 for Patients With Relapsed or Refractory Cancers
| Autor: | Babak Nikkholgh, Seyed Javad Rekabpour, Sakineh Ebrahimi, Nader Shakibazad, Hamidreza Amini, Majid Assadi, Hojjat Ahmadzadehfar, Narges Jokar, Hassan Kamali, Iraj Nabipour, Esmail Jafari, Ghasemali Divband |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Biodistribution Adolescent Phases of clinical research Young Adult Refractory Fibroblast activation protein alpha Neoplasms Internal medicine medicine Humans Tissue Distribution Radiology Nuclear Medicine and imaging Child Aged Radioisotopes business.industry Cancer Common Terminology Criteria for Adverse Events General Medicine Fibroblasts Middle Aged medicine.disease Toxicity Radionuclide therapy Quinolines Feasibility Studies Female business |
| Zdroj: | Clinical Nuclear Medicine. 46:e523-e530 |
| ISSN: | 1536-0229 0363-9762 |
| DOI: | 10.1097/rlu.0000000000003810 |
| Popis: | Introduction Fibroblast activation protein (FAP) is a member of the serine protease family and has a high expression in the stroma of approximately 90% of epithelial malignancies. The present investigation aimed to assess the feasibility, safety, and dosimetry data of 177Lu-FAPI-46 in diverse malignancies. Patients and methods Patients with advanced cancers with nonoperable tumors, or tumors refractory to conventional therapies, were enrolled. Treatment included escalating doses of 177Lu-FAPI-46 (1.85-4.44 GBq) per cycle using a combination of clinical and statistical expertise design, and intervals of 4 to 6 weeks were considered between the cycles. Biodistribution and dosimetry were examined by whole-body scans. We applied the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.03 to measure peptide-targeted radionuclide therapy (PTRT)-associated toxicity. Results A total of 21 patients (11 females and 10 males) with a median age of 50 years (range, 6-79 years) were investigated. Of 21 participants, 18 cases were selected for PTRT. Overall, 36 PTRT cycles were performed. The median number of PTRT cycles and the median injected amount of activity in each cycle were 2 and 3.7 GBq, respectively. The dosimetric analysis revealed median absorbed doses of 0.026, 0.136, 0.886, and 0.02 with ranges of 0.023-0.034, 0.001-0.2, 0.076-1.39, and 0.002-0.2 mGy/MBq for the whole body, liver, kidneys, and spleen, respectively. The therapy was well tolerated in almost all patients. Conclusions The findings of this preliminary investigation might indicate the potential feasibility and safety of PTRT using 177Lu-FAPI-46 for different aggressive tumors. Moreover, the current study could be beneficial in determining the suitable amount of activity for a phase 2 study. |
| Databáze: | OpenAIRE |
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