TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes

Autor: Michael Eyres, Christine Blancher, Andrew Blake, Frances Willenbrock, Dimitris Vavoulis, Michael Silva, Zahir Soonawalla, Daniel S.T. Hughes, Aswin George Abraham, Haonan Xu, Stephanie Jones, Asmita Thapa, S. M. Hughes, Robert D. Goldin, Eric O'Neill, Anna Schuh, Ahmad Sabbagh, Adam Burns, Simone Lanfredini, Clare Verrill, Somnath Mukherjee, Zenobia D’Costa, Tim Maughan, Aline Hubert
Rok vydání: 2020
Předmět:
0301 basic medicine
Epigenomics
Transcription
Genetic
Bisulfite sequencing
Ascorbic Acid
SMAD4
Epigenesis
Genetic
Transcriptome
Epigenome
0302 clinical medicine
GATA6 Transcription Factor
Antineoplastic Combined Chemotherapy Protocols
Wnt Signaling Pathway
Smad4 Protein
GATA6
Gastroenterology
Cell Differentiation
Phenotype
Metformin
DNA-Binding Proteins
Gene Expression Regulation
Neoplastic
5-Methylcytosine
030211 gastroenterology & hepatology
Epigenetics
Carcinoma
Pancreatic Ductal
Mice
Nude
Mice
Transgenic
Biology
Dioxygenases
03 medical and health sciences
Pancreatic Cancer
Pancreatic cancer
Cell Line
Tumor
medicine
Biomarkers
Tumor
Animals
Humans
RSPO1
Retrospective Studies
TET2
Hepatology
Gastroenterology & Hepatology
Gene Expression Profiling
1103 Clinical Sciences
DNA Methylation
medicine.disease
Ascorbic acid
Xenograft Model Antitumor Assays
Pancreatic Neoplasms
030104 developmental biology
Cancer research
1114 Paediatrics and Reproductive Medicine
1109 Neurosciences
Zdroj: 668.e16
ISSN: 1528-0012
Popis: BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is characterized by advanced disease stage at presentation, aggressive disease biology, and resistance to therapy, resulting in an extremely poor 5-year survival rate of
Databáze: OpenAIRE
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