Associative Overdominance and Negative Epistasis Shape Genome-Wide Ancestry Landscape in Supplemented Fish Populations
| Autor: | Hugo Cayuela, Maeva Leitwein, Louis Bernatchez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0301 basic medicine Genotype lcsh:QH426-470 Trout Outbreeding depression Population salmonid introgression Introgression Overdominance Biology associative-overdominance (AOD) stocking 010603 evolutionary biology 01 natural sciences Polymorphism Single Nucleotide Article Evolution Molecular 03 medical and health sciences Genetic drift Genetics Animals education Genetics (clinical) Genes Dominant associative-overdominance (AOD) Population Density Genetic diversity education.field_of_study Genome Strain (biology) Genetic Drift genomic landscape Epistasis Genetic stocking lcsh:Genetics 030104 developmental biology Genetics Population evolutionary mechanisms Evolutionary biology Epistasis |
| Zdroj: | Genes Volume 12 Issue 4 Genes, Vol 12, Iss 524, p 524 (2021) |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes12040524 |
| Popis: | The interplay between recombination rate, genetic drift and selection modulates variation in genome-wide ancestry. Understanding the selective processes at play is of prime importance toward predicting potential beneficial or negative effects of supplementation with domestic strains (i.e., human-introduced strains). In a system of lacustrine populations supplemented with a single domestic strain, we documented how population genetic diversity and stocking intensity produced lake-specific patterns of domestic ancestry by taking the species’ local recombination rate into consideration. We used 552 Brook Charr (Salvelinus fontinalis) from 22 small lacustrine populations, genotyped at ~32,400 mapped SNPs. We observed highly variable patterns of domestic ancestry between each of the 22 populations without any consistency in introgression patterns of the domestic ancestry. Our results suggest that such lake-specific ancestry patterns were mainly due to variable associative overdominance (AOD) effects among populations (i.e., potential positive effects due to the masking of possible deleterious alleles in low recombining regions). Signatures of AOD effects were also emphasized by highly variable patterns of genetic diversity among and within lakes, potentially driven by predominant genetic drift in those small isolated populations. Local negative effects such as negative epistasis (i.e., potential genetic incompatibilities between the native and the introduced population) potentially reflecting precursory signs of outbreeding depression were also observed at a chromosomal scale. Consequently, in order to improve conservation practices and management strategies, it became necessary to assess the consequences of supplementation at the population level by taking into account both genetic diversity and stocking intensity when available. |
| Databáze: | OpenAIRE |
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