Cryopreserved autologous bone marrow transplantation in patients with acute nonlymphoid leukemia: chemotherapy before harvesting is the main factor in delaying hematological recovery
| Autor: | Dinota A, Patrizia Tosi, Giuseppe Visani, Simonetta Rizzi, Maria Rosa Motta, Giuseppe Bandini, A. Cenacchi, Miriam Fogli, Sante Tura, Livia Albertazzi, F. Verlicchi, R. Colombini, Roberto M. Lemoli, Paolo Ricci |
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| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Pathology medicine.medical_treatment Transplantation Autologous General Biochemistry Genetics and Molecular Biology Cryopreservation immune system diseases hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Bone Marrow Transplantation Chemotherapy business.industry Lymphoma Non-Hodgkin General Medicine medicine.disease Autologous bone Combined Modality Therapy Hematopoiesis Lymphoma Kinetics Leukemia Myeloid Acute Haematopoiesis Leukemia medicine.anatomical_structure Bone marrow Stem cell General Agricultural and Biological Sciences business |
| Popis: | We analyzed the kinetics of hematological recovery after autologous bone marrow transplantation in 13 patients with acute nonlymphoid leukemias (ANLL). A comparison was made with 31 patients with non-Hodgkin's lymphoma (NHL) whose bone marrow was harvested and cryopreserved, either at diagnosis or after intensive chemotherapy. Hematological recovery of ANLL patients was similar to that of pretreated NHL patients and significantly slower than that of untreated NHL patients. We suggest that chemotherapy before harvest (more than the possible decreased stem cell marrow potentiality resulting from the underlying disease) appears to be the main factor responsible for delayed recovery after autologous bone marrow transplantation in ANLL. |
| Databáze: | OpenAIRE |
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