Vinflunine in the treatment of relapsed metastatic urothelial cancer: A systematic review and meta-analysis of real-world series
| Autor: | Jacques Medioni, Anders Ullén, Laura Doni, Syed A. Hussain, Rodolfo Passalacqua, Daniel Castellano, Aristotelis Bamias, Axel Hegele, Flora Zagouri, Kimon Tzannis |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Oncology Urologic Neoplasms medicine.medical_specialty Vomiting Nausea medicine.medical_treatment MEDLINE Platinum Compounds Neutropenia Vinblastine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Recurrence Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans Medicine Neoplasm Metastasis Fatigue Aged Chemotherapy Vinflunine business.industry Hematology Middle Aged medicine.disease Europe Clinical trial Treatment Outcome 030104 developmental biology chemistry 030220 oncology & carcinogenesis Meta-analysis Female medicine.symptom business Constipation |
| Zdroj: | Critical Reviews in Oncology/Hematology. 140:80-87 |
| ISSN: | 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2019.05.006 |
| Popis: | Background. Vinflunine (VFL) is approved in Europe as second-line treatment of metastatic urothelial cancer after failure of platinum-containing therapy. We performed a systematic review and meta-analysis of real-world data (RWD) to assess utilization, efficacy and safety of VFL. \ud \ud Methods. We performed a MEDLINE search for the period of 1/1/2000-31/8/2017. Full-length articles providing post-marketing RWD on VFL in patients failing previous chemotherapy were eligible. Interventional clinical trials were excluded. \ud \ud Results: Ten studies with 797 patients were identified. According to pooled REs analysis, overall response rate was 19%, most frequent, all-grade toxicities were fatigue (41%), constipation (39%), nausea/vomiting (25%), and most prevalent Grade 3–4 toxicities were neutropenia (13%), anaemia (9%), fatigue (8%). Median OS was comparable to results reported in recent randomized studies.\ud \ud Conclusion. Our findings confirm the efficacy and safety of VFL in an unselected population and support the use of VFL in the changing treatment paradigm of relapsed mUC. |
| Databáze: | OpenAIRE |
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