Peptide Self-Assemblies from Unusual α-Sheet Conformations Based on Alternation of d/l Amino Acids

Autor:	Peng Zhou, Xuzhi Hu, Jie Li, Yan Wang, Henghao Yu, Zhaoyu Chen, Dong Wang, Yurong Zhao, Stephen M. King, Sarah E. Rogers, Jiqian Wang, Jian Ren Lu, Hai Xu
Rok vydání:	2022
Předmět:	Colloid and Surface Chemistry Circular Dichroism Protein Conformation beta-Strand General Chemistry Amino Acids Peptides Biochemistry Catalysis Protein Structure Secondary
Zdroj:	Journal of the American Chemical Society. 144(47)
ISSN:	1520-5126
Popis:	Peptide self-assembly is a hierarchical process during which secondary structures formed in the initial stages play a critical role in determining the subsequent assembling processes and final structural ordering. Unusual secondary structures hold promise as a source to develop novel supramolecular architectures with unique properties. In this work, we report the design of a new peptide self-assembly strategy based on unusual α-sheet secondary structures. In light of the strong propensity of leucine toward forming helical conformations and its high hydrophobicity, we design two short amphiphilic peptides Ac-L
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f78467d08c0356de9ee817f4170d3e0 https://pubmed.ncbi.nlm.nih.gov/36345816 Zobrazit plný text záznamu