Malignant Oestrogen-producing Teratoma in a Cat
| Autor: | Masaki Michishita, Kimimasa Takahashi, K. Taya, Tatsuya Hori, Miho Wada, Eiichi Kawakami, Kozo Ohkusu-Tsukada, Yukino Machida, Hisashi Yoshimura |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pathology 040301 veterinary sciences Adipose tissue Biology Cat Diseases Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Animals Aromatase Ovarian Neoplasms General Veterinary Cartilage Mesenchymal stem cell Teratoma Estrogens 04 agricultural and veterinary sciences Abdominal distension medicine.disease Immunohistochemistry Epithelium medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis Cats biology.protein Female medicine.symptom |
| Zdroj: | Journal of Comparative Pathology. 156:178-182 |
| ISSN: | 0021-9975 |
| DOI: | 10.1016/j.jcpa.2016.11.273 |
| Popis: | A 5-year-old female domestic shorthair cat was presented with abdominal distension and serum biochemical evaluation indicated a high concentration of oestradiol (32.81 pg/ml). Exploratory laparotomy revealed a large cystic mass in the right ovary with cystic fluid containing a high level of oestradiol (18.80 pg/ml). The tumour was composed of immature neuroectodermal tissue, mature cartilage, smooth muscle, adipose tissue and aggregated, poorly differentiated mesenchymal cells. It contained cysts of various sizes that were lined by epithelium of different types. The basal layer of the lining epithelium was shown to express aromatase by immunohistochemistry. The findings suggest that this was a novel, malignant, oestrogen-secreting teratoma and that the aromatase-positive, neoplastic cells may have been the source of elevated levels of serum oestrogen. |
| Databáze: | OpenAIRE |
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