Volumetric histograms-based analysis of apparent diffusion coefficients and standard uptake values for the assessment of pediatric sarcoma at staging: preliminary results of a PET/MRI study
| Autor: | Alessandro Spimpolo, Roberto Stramare, Pietro Zucchetta, Gianni Bisogno, Chiara Giraudo, Filippo Crimì, Giovanna Orsatti, Diego Cecchin, Alessia Varotto, Michael Weber |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Histograms Population Bone Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences symbols.namesake 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging education Child Neuroradiology Retrospective Studies education.field_of_study Pediatric sarcoma business.industry Ultrasound Sarcoma General Medicine medicine.disease Magnetic Resonance Imaging Pearson product-moment correlation coefficient SUV body regions PET/MRI ADC Skewness 030220 oncology & carcinogenesis Positron-Emission Tomography symbols Kurtosis Female business Nuclear medicine Diffusion MRI Follow-Up Studies |
| Zdroj: | La Radiologia medica. 126(6) |
| ISSN: | 1826-6983 |
| Popis: | To assess the relationship between apparent diffusion coefficients (ADC) and standard uptake values (SUV) of pediatric sarcomas at staging by using volumetric histograms analyses. Children with histologically proven sarcoma, referring to our tertiary center for a whole-body 18F-FDG PET/MRI for staging and including diffusion weighted imaging in the MRI protocol were investigated. Firstly, turbo inversion recovery magnitude (TIRM) and PET images were resliced and resampled according to the ADC maps. Regions of interests were drawn along tumor margins on TIRM images and then copied on PET and ADC datasets. Pixel-based SUVs and ADCs were collected from the entire volume of each lesion. Mean, median, skewness, and kurtosis of SUVs and ADCs values were computed, and the Pearson correlation coefficient was then applied (for the entire population and for histological subgroups with more than five patients). Thirteen patients met the inclusion criteria (six females; mean age 8.31 ± 6.03 years). Histology revealed nine rhabdomyosarcomas, three Ewing sarcomas, and one chondroblastic osteosarcoma. A significant negative correlation between ADCs’ and SUVs’ mean (rmean = − 0.501, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink