Neuro-protective role of nanocapsulated curcumin against cerebral ischemia-reperfusion induced oxidative injury
| Autor: | Snehasikta Swarnakar, Sayantan Jana, Abhishek Mukherjee, Sibani Sarkar, Nirmalendu Das |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Curcumin Antioxidant medicine.medical_treatment Ischemia Apoptosis Pharmacology Blood–brain barrier Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Nanocapsules medicine Animals Molecular Biology chemistry.chemical_classification Reactive oxygen species General Neuroscience Neurodegeneration Brain medicine.disease Rats Oxidative Stress PLGA Neuroprotective Agents 030104 developmental biology medicine.anatomical_structure chemistry Reperfusion Injury Female Lipid Peroxidation Neurology (clinical) Reactive Oxygen Species 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Brain Research. 1704:164-173 |
| ISSN: | 0006-8993 |
| Popis: | Cerebral ischemia-reperfusion (CIR) accelerates the progression of neurodegeneration by causing mitochondrial dysfunction to overproduce reactive oxygen species (ROS). Curcumin shows protective effects against CIR-induced oxidative damage. Free curcumin (FC) is effective at high doses due to its poor bioavailability. Also the blood-brain barrier (BBB) limits the passage of substances from circulation into the cerebral region. Thus, formulation of curcumin within polyethylene glycol (PEG)-ylated polylactide-co-glycolide (PLGA) nanoparticles (NC) was applied orally to aged rats to explore its role against CIR injury. Mitochondrial damage was evaluated. The levels of pro-inflammatory cytokines and components of apoptotic pathway were studied. Unlike FC, NC pre-treatment exerted better neuro-protection by ameliorating ROS-mediated oxidative damage and prevented CIR-induced neuronal apoptosis. Therefore, curcumin incorporated PEGylated PLGA nanoparticles may be used as a suitable delivery vehicle to the brain as they can increase curcumin bioavalability and the released curcumin may confer protection to the neurons against CIR-induced oxidative damage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect