Reduced Sympathetic Stimulus and Angiotensin 1–7 Are Related to Diastolic Dysfunction in Spinal Cord–Injured Subjects
| Autor: | Eliza Regina Ferreira Braga Machado de Azevedo, José Irineu Gorla, Dulce Elena Casarini, Zaira Palomino, Guilherme de Rossi, Wilson Nadruz, Roberto Schreiber, Andrei C. Sposito, José R. Matos-Souza, Karina Cristina Alonso, Alberto Cliquet, Layde R. Paim, Anselmo de Athayde Costa e Silva, Claudio Diehl Nogueira |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Sympathetic Nervous System Diastole Hemodynamics 030204 cardiovascular system & hematology Ventricular Function Left Renin-Angiotensin System Norepinephrine 03 medical and health sciences 0302 clinical medicine Internal medicine Renin–angiotensin system medicine Humans Spinal cord injury Tetraplegia Spinal Cord Injuries business.industry Spinal cord medicine.disease Angiotensin II Peptide Fragments medicine.anatomical_structure Endocrinology Neurology (clinical) Angiotensin I business Paraplegia 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma. 34:2323-2328 |
| ISSN: | 1557-9042 0897-7151 |
| Popis: | Chronic spinal cord injury (SCI) is often associated with reductions in left ventricular (LV) diastolic function. Impairments in sympathetic activity and activation of the renin-angiotensin system are reported in SCI individuals and may hypothetically be implicated in this association. Hence, the present study verified the relationship between these two neuro-hormonal and cardiac functional and structural characteristics in SCI individuals. Twenty-two men with SCI (injury level above T6 and no voluntary motion below the injury) and 11 able-bodied men were evaluated by clinical, hemodynamic, laboratory, and echocardiographic analysis and had plasmatic renin, angiotensin I (ANGI), angiotensin II (ANGII), angiotensin 1-7 (ANG1-7), and noradrenaline levels measured. SCI subjects had lower noradrenaline (p = 0.003) and higher ANG1-7 (p = 0.009), but similar renin, ANGI, and ANGII levels when compared with able-bodied individuals. In SCI individuals, results of multi-variable analysis showed that higher Em, a marker of better LV diastolic function, was directly associated with ANG1-7 (p = 0.05) or ANG1-7/ANGII ratio (p = 0.007), whereas lower noradrenaline levels were independently associated with worse LV diastolic function, as assessed by E/Em ratio (p = 0.028). In conclusion, these results suggest that reduced sympathetic activity and expression of ANG1-7 may be involved in SCI-related diastolic dysfunction. |
| Databáze: | OpenAIRE |
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