Single use and conventional bronchoscopes for Broncho alveolar lavage (BAL) in research: a comparative study (NCT 02515591)
| Autor: | Angela D. Wright, Andrea M. Collins, Seher Zaidi, Kayleigh Davies, Jesús Reiné, Jessica T. Owugha, Jamie Rylance, Amitava Ganguli, Richard Fitzgerald, Daniela M. Ferreira, Elena Mitsi, Stephen B. Gordon |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Single use bronchoscopes Pulmonary and Respiratory Medicine medicine.medical_specialty Biomedical Research Research Bronchoscopy Cell Survival medicine.medical_treatment Context (language use) Bronchoalveolar Lavage Bronchoscopies Young Adult 03 medical and health sciences 0302 clinical medicine Bronchoscopy medicine Humans Intubation Durable Medical Equipment wb_293 Prospective Studies 030212 general & internal medicine Bronchoscopes Disposable Equipment Saline Lung diseases lcsh:RC705-779 Cross Infection medicine.diagnostic_test business.industry Bronchoalveolar lavage fluid lcsh:Diseases of the respiratory system Healthy Volunteers 3. Good health Surgery wf_20 Clinical trial Bronchoalveolar lavage 030228 respiratory system Female wf_100 business wf_600 Research Article |
| Zdroj: | BMC Pulmonary Medicine, Vol 17, Iss 1, Pp 1-5 (2017) BMC Pulmonary Medicine |
| ISSN: | 1471-2466 |
| Popis: | Background\ud Broncho alveolar lavage (BAL) is widely used for investigative research to study innate, cellular and humoral immune responses, and in early phase drug trials. Conventional (multiple use) flexible bronchoscopes have time and monetary costs associated with cleaning, and carries a small risk of cross infection. Single use bronchoscopes may provide an alternative, but have not been evaluated in this context.\ud \ud \ud Methods\ud Healthy volunteers underwent bronchoscopy at a day-case clinical research unit using the Ambu® aScopeTM single-use flexible intubation bronchoscope. Broncho alveolar lavage was performed from a sub segmental bronchus within the right middle lobe; a total of 200 ml of warmed normal saline was instilled then aspirated using handheld suction. BAL volume yield, cell yield and viability were recorded.\ud \ud \ud Results\ud Ten volunteers, (mean age 23 years, six male) participated. Bronchoscopies were carried out by one of two senior bronchoscopists, experienced in the technique of obtaining BAL for research purposes. The results were compared to 50 (mean age 23, 14 male) procedures performed using the conventional scope by the same two bronchoscopists. The total volume yield was significantly higher in the disposable group median 152 ml (IQR 141–166 ml) as compared to conventional 124 ml (110–135 ml), p = |
| Databáze: | OpenAIRE |
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