Exaggerated natriuresis during clamping of systemic NO supply in healthy young men
| Autor: | Poul Flemming Høilund-Carlsen, Mona Sommer Rasmussen, Peter Bie, Werner Vach, Jane Angel Simonsen |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Nitroprusside medicine.medical_specialty Renal Plasma Flow Natriuresis Renal function Sodium Chloride Nitric Oxide Models Biological Renin-Angiotensin System Excretion Young Adult chemistry.chemical_compound Internal medicine Renin–angiotensin system medicine Humans Nitric Oxide Donors Enzyme Inhibitors Aldosterone Chemistry Angiotensin II Hemodynamics General Medicine NG-Nitroarginine Methyl Ester Endocrinology Renal blood flow Sodium nitroprusside Nitric Oxide Synthase Glomerular Filtration Rate medicine.drug |
| Zdroj: | Simonsen, J A, Rasmussen, M S, Vach, W, Høilund-Carlsen, P F & Bie, P 2012, ' Exaggerated natriuresis during clamping of systemic NO supply in healthy young men ', Clinical Science, vol. 122, no. 2, pp. 63-73 . https://doi.org/10.1042/CS20110144 |
| ISSN: | 1470-8736 0143-5221 |
| Popis: | NO (nitric oxide) may be involved in fluid homoeostasis. We hypothesized that increases in NO synthesis contribute to acute, saline-induced natriuresis, which, therefore, should be blunted when NO availability is stabilized. Young men were studied during simultaneous infusions of L-NAME [NG-nitro-L-arginine methyl ester; bolus of 750 μg·kg−1 of body weight and 8.3 μg·min−1·kg−1 of body weight] and SNP (sodium nitroprusside), the latter at a rate preventing L-NAME from increasing total peripheral resistance (‘NO-clamping’). Slow volume expansion (saline, 20 μmol of NaCl·min−1·kg−1 of body weight for 3 h) was performed with and without concomitant NO-clamping. NO-clamping itself decreased RPF (renal plasma flow; P~0.02) and tended to decrease arterial blood pressure [MABP (mean arterial blood pressure)]. Volume expansion markedly decreased the plasma levels of renin, AngII (angiotensin II) and aldosterone (all P |
| Databáze: | OpenAIRE |
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