Lanthanide co-doped paramagnetic spindle-like mesocrystals for imaging and autophagy induction
| Autor: | Pan Xiaofeng, Li Zhang, Yang Zhao, Liang Dong, Yun-Jun Xu, Sheng-Liang Zhong, Jun Lin, Wei Zhou, Longping Wen, Jun Peng, Yang Lu, Lei Wang, Ya-Dong Wu, Shu-Hong Yu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Lanthanide
Fluorescence-lifetime imaging microscopy Materials science Autophagy Dual mode Contrast Media 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Haemolysis 01 natural sciences Fluorescence Lanthanoid Series Elements Magnetic Resonance Imaging 0104 chemical sciences Paramagnetism Phosphatidylinositol 3-Kinases Nuclear magnetic resonance Biophysics Humans General Materials Science 0210 nano-technology Co doped HeLa Cells |
| Zdroj: | Nanoscale. 8(27) |
| ISSN: | 2040-3372 |
| Popis: | We synthesized two novel lanthanide doped spindle-like mesocrystals, YF3:Ce,Eu,Gd and YF3:Ce,Tb,Gd (abbreviated as YEG and YTG mesospindles, respectively). Both of them possess paramagnetic and fluorescent properties, and their excellent cyto-compatibility and low haemolysis are further confirmed. Therefore, they could act as dual mode contrast agents for magnetic resonance imaging (MRI) and fluorescence imaging. Furthermore, YEG and YTG mesospindles induce dose and time dependent autophagy by activating the PI3K signaling pathway. The autophagy induced by YEG and YTG mesocrystals is confirmed by enhanced autophagosome formation, normal cargo degradation, and no disruption of lysosomal function. This work is important to illustrate how rare-earth mesocrystals affect the autophagic pathway, indicating the potential of the YEG and YTG mesospindles in diagnosis and therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|