Male aromatase-knockout mice exhibit normal levels of activity, anxiety and 'depressive-like' symptomatology
| Autor: | Jacques Balthazart, Christina Dalla, Julie Bakker, Katerina Antoniou, Zeta Papadopoulou-Daifoti |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Exploratory Behavior/physiology
Male Elevated plus maze medicine.medical_specialty Stress Physiological/physiopathology Time Factors medicine.drug_class Anxiety Motor Activity Open field Behavioral Neuroscience Mice Aromatase Stress Physiological Internal medicine medicine Animals Aromatase/*deficiency Maze Learning Swimming Testosterone Mice Knockout Analysis of Variance biology Behavior Animal Depression Depression/*genetics/physiopathology medicine.disease Endocrinology Estrogen Maze Learning/physiology Knockout mouse Exploratory Behavior biology.protein Swimming/physiology Mice Knockout/*physiology Psychology Aromatase deficiency Anxiety/*genetics/physiopathology Behavioural despair test Motor Activity/*genetics |
| Popis: | It is well known that estradiol derived from neural aromatization of testosterone plays a crucial role in the development of the male brain and the display of sexual behaviors in adulthood. It was recently found that male aromatase knockout mice (ArKO) deficient in estradiol due to a mutation in the aromatase gene have general deficits in coital behavior and are sexually less motivated. We wondered whether these behavioral deficits of ArKO males could be related to changes in activity, exploration, anxiety and "depressive-like" symptomatology. ArKO and wild type (WT) males were subjected to open field (OF), elevated plus maze (EPM), and forced swim tests (FST), after being exposed or not to chronic mild stress (CMS). CMS was used to evaluate the impact of chronic stressful procedures and to unveil possible differences between genotypes. There was no effect of genotype on OF, EPM and FST behavioral parameters. WT and ArKO mice exposed to CMS or not exhibited the same behavioral profile during these three types of tests. However, all CMS-exposed mice (ArKO and WT) spent less time in the center of the EPM. Additionally, floating duration measured in the FST increased between two tests in both WT and ArKO mice, though that increase was less prominent in mice previously subjected to CMS than in controls. Therefore, both ArKO and WT males displayed the same behavior and had the same response to CMS however CMS exposure slightly modified the behavior displayed by mice of both genotypes in the FST and EPM paradigms. These results show that ArKO males display normal levels of activity, exploration, anxiety and "depressive-like" symptomatology and thus their deficits in sexual behavior are specific in nature and do not result indirectly from other behavioral changes. Behav Brain Res |
| Databáze: | OpenAIRE |
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