Risk factors for quinolone-resistant Escherichia coli infection: a systematic review and meta-analysis
Autor: | Yan Shen, Qin Zhang, Qiu-Hong Li, Dong-Mei Zhu |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Microbiology (medical) Male medicine.medical_specialty Quinolone 030106 microbiology Resistance Disease Drug resistance Cochrane Library Quinolones lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Medical microbiology Risk Factors Internal medicine Drug Resistance Bacterial medicine Escherichia coli Odds Ratio Humans lcsh:RC109-216 Pharmacology (medical) 030212 general & internal medicine Risk factor Escherichia coli Infections Sex Characteristics business.industry Research Public Health Environmental and Occupational Health Odds ratio Transplantation Meta-analysis Infectious Diseases Female business Infection |
Zdroj: | Antimicrobial Resistance and Infection Control Antimicrobial Resistance and Infection Control, Vol 9, Iss 1, Pp 1-11 (2020) |
ISSN: | 2047-2994 |
Popis: | Background Antimicrobial resistance to quinolone is rising worldwide, especially in Escherichia coli causing various infections. Although many studies have been conducted to identify the risk factors for quinolone-resistant Escherichia coli (QREC) infection, the results are inconsistent and have not been systematically reported. The aim of the present study is to conduct a systematic review and meta-analysis to evaluate the potential risk factors for QREC infection. Methods A systematic search was performed to collect published data in the EMBASE, PubMed, and the Cochrane Library up to April 2019. Risk factors were analyzed using the pooled odds ratio (ORs) with 95% confidence interval (CIs). Results Twenty-seven trials involving 67,019 participants were included in the present study. The following risk factors associated with QREC infection were identified: (1) male (OR = 1.41), (2) hepatic cirrhosis (OR = 2.05), (3) diabetes mellitus (OR = 1.62), (4) cardiovascular disease (OR = 1.76), (5) neurogenic bladder (OR = 8.66), (6) renal dysfunction (OR = 2.47), (7) transplantation (OR = 2.37), (8) urinary tract infection (OR = 2.79) and urinary tract abnormality (OR = 1.85), (9) dementia (OR = 5.83), (10) heart failure (OR = 5.63), (11) neurologic disease (OR = 2.80), (12) immunosuppressive drugs (OR = 2.02), (13) urinary catheter (OR = 4.39), (14) nursing home resident (OR = 4.63), (15) prior surgery (OR = 2.54), (16) quinolones (OR = 7.67), (17) other antibiotics (OR = 2.74), (18) hospitalization (OR = 2.06) and (19) nosocomial infection acquisition (OR = 2.35). Conclusions QREC infection was associated with nineteen risk factors including prior quinolones use, hospitalization, and several comorbidities. Reducing exposure to these risk factors and modification of antibiotic use are important to prevent quinolone resistance. |
Databáze: | OpenAIRE |
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