Molecular Characterization of Reactive Oxygen Species in Systemic and Pulmonary Hypertension
| Autor: | Bradley A. Rose, Feng He, Amy Banes-Berceli, William J. Roberts, Li Zuo |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Hypertension
Pulmonary Blood Pressure Pulmonary Artery Pharmacology Antioxidants Nitric oxide chemistry.chemical_compound Internal Medicine medicine Animals Humans Antihypertensive Agents chemistry.chemical_classification Reactive oxygen species business.industry medicine.disease Angiotensin II Pulmonary hypertension Blood pressure chemistry Hypertension Immunology Signal transduction Reactive Oxygen Species Janus kinase business Nicotinamide adenine dinucleotide phosphate Signal Transduction |
| Zdroj: | American Journal of Hypertension. 27:643-650 |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/hpt292 |
| Popis: | Hypertension, commonly recognized as high blood pressure, is a serious disease that affects millions of people worldwide. Similar to many physiological disorders, hypertension consists of several different cellular signaling pathways that involve various molecular messengers. Recent studies have shown that reactive oxygen species (ROS) play a substantial role in the development of both systemic and pulmonary hypertension, contributing to the pathology of this disease. However, the exact molecular mechanism of ROS in hypertension is not completely understood. In this review, we extensively examine and discuss the most recent experimental findings regarding the role of ROS in both pulmonary and systemic hypertension. Current studies show that excessive ROS not only promote JAK/STAT (janus kinase/signal transducers and activators of transcription)-mediated vascular remodeling in an angiotensin (ANG) II-induced hypertension model but also decrease the nitric oxide bioavailability. Furthermore, it has been shown that ROS generation can be mitigated through the inhibition of upstream ANG II or by blocking key ROS generators, such as nicotinamide adenine dinucleotide phosphate oxidase. Thus, various treatment options have been explored. Yet, as discussed in the current review, the regulation of ROS via novel antioxidant therapies may provide an alternative treatment for hypertension in the future. |
| Databáze: | OpenAIRE |
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